RD TOCRIS一级代理，Z-Guggulsterone供应CAS号39025-23-5我公司代理RD产品和tocris产品Z-Guggulsterone货号：3570规格：10mg，50mg

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RD TOCRIS一级代理，Z-Guggulsterone供应CAS号39025-23-5

Catalog Number:3570

Chemical Name:(Z)-Pregna-4,17(20)-diene-3,16-dione

详细产品信息：

Biological ActivityBroad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Kivalues are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (Ki= 315 nM). Induces apoptosis in prostate cancer cells and inhibits angiogenesis via suppression of the VEGF-VEGFR2-Akt signaling pathway. Exhibits antilipidemic activity via antagonism of the farnesoid X receptor (FXR) and displays antiseptic, antirheumatic and anti-inflammatory activityin vivo. More active isomer ofguggulsterone(Cat. No. 2013).

Technical Data

• M.Wt:

  312.45

• Formula:

  C21H28O2

• Solubility:

  Soluble to 20 mM in DMSO with gentle warming and to 10 mM in ethanol with gentle warming

• Purity:

  >98%

• Storage:

  Store at RT

• CAS No:

  39025-23-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.