Thapsigargin≥98% (HPLC), solid film solubility:DMSO: soluble ethanol: soluble
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Biochem/physiol Actions
Potent, cell-permeable, IP3-independent intracellular calcium releaser. Blocks the transient increase in intracellular Ca2+ induced by angiostatin and endostatin. Induces apoptosis by disrupting intracellular free Ca2+ levels; incorporated into chemotherapeutic prodrug formulations.
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