Applications

FA

Synonyms:

CHEMBL573107, GTPL8038, AB0007926, S14-0516, 2-[ AMINO]-7,8-DIHYDRO-5,7-DIMETHYL-8- -6 -PTERIDINONE

Formulation:

Crystalline solid

Chemical Name:

2-(3,5-difluoro-4-hydroxyanilino)-5,7-dimethyl-8-(3-methylbutyl)-7H-pteridin-6-one

Molecular Formula:

C₁₉H₂₃F₂N₅O₂

Molecular Weight:

391.4

CAS Number

501437-28-1

Purity:

≥95%

Storage Conditions:

Product should be kept at -20°C.

References:

Neise, D., Sohn, D., Stefanski, A., Goto, H., Inagaki, M., Wesselborg, S., ... & Jänicke, R. U. (2013). The p90 ribosomal S6 kinase (RSK) inhibitor BI-D1870 prevents gamma irradiation-induced apoptosis and mediates senescence via RSK-and p53-independent accumulation of p21WAF1/CIP1.Cell death & disease,4(10), e859.

Nguyen, T. L. (2008). Targeting RSK: an overview of small molecule inhibitors.Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents),8(7), 710-716.

Sapkota, G., Cummings, L., Newell, F., Armstrong, C., Bain, J., Frodin, M., ... & Alessi, D. (2007). BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo.Biochem. J,401, 29-38.