Applications

FA

Synonyms:

gamma-Secretase Inhibitor IX, GSI IX, N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine tert-butyl ester

Formulation:

Crystalline solid

Chemical Name:

tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate

Molecular Formula:

C₂₃H₂₆F₂N₂O₄

Molecular Weight:

432.5

CAS Number

208255-80-5

Purity:

≥95%

Storage Conditions:

Product should be kept at -20°C.

References:

El Mouedden, M., Vandermeeren, M., Meert, T., & Mercken, M. (2005). Reduction of Abeta levels in the Sprague Dawley rat after oral administration of the functional gamma-secretase inhibitor, DAPT: a novel non-transgenic model for Abeta production inhibitors.Current pharmaceutical design,12(6), 671-676.

Yagishita, S., Morishima-Kawashima, M., Tanimura, Y., Ishiura, S., & Ihara, Y. (2006). DAPT-induced intracellular accumulations of longer amyloid β-proteins: further implications for the mechanism of intramembrane cleavage by γ-secretase.Biochemistry,45(12), 3952-3960.

Crawford, T. Q., & Roelink, H. (2007). The Notch response inhibitor DAPT enhances neuronal differentiation in embryonic stem cell‐derived embryoid bodies independently of sonic hedgehog signaling.Developmental Dynamics,236(3), 886-892.

Grottkau, B. E., Friedrich, C. C., Jing, W., & Wu, Y. (2009). DAPT enhances the apoptosis of human tongue carcinoma cells.International journal of oral science,1(2), 81-89.