Applications

FA

Synonyms:

Fingolimod hydrochloride, Fty-720, Fingolimod HCl

Formulation:

Crystalline solid

Chemical Name:

2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol;hydrochloride

Molecular Formula:

C₁₉H₃₃NO₂HCl

Molecular Weight:

343.9

CAS Number

162359-56-0

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Brinkmann, V., Davis, M. D., Heise, C. E., Albert, R., Cottens, S., Hof, R., ... & Lynch, K. R. (2002). The immune modulator FTY720 targets sphingosine 1-phosphate receptors.Journal of Biological Chemistry,277(24), 21453-21457.

Gräler, M. H., & Goetzl, E. J. (2004). The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors.The FASEB journal,18(3), 551-553.

Chiba, K., Yanagawa, Y., Masubuchi, Y., Kataoka, H., Kawaguchi, T., Ohtsuki, M., & Hoshino, Y. (1998). FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing.The Journal of Immunology,160(10), 5037-5044.