IDE2

2024-10-15

IDE2

货号:1139374-1,1139374-10

规格:1mg,10mg

价格:330,1815

产品类型:小分子化合物

品牌:Biogems

Catalogue Number :1139374

Description

IDE2 activates the TGF-beta signaling pathway and induces definitive endoderm formation in human and mouse embryonic stem cells. It is also reported to increase the levels of Nodal expression, induce Smad2 phosphorylation and SOX17 expression.

Additional Information

Applications

FA

Synonyms:

1DE 2, Inducer of Definitive Endoderm 2

Formulation:

Crystalline solid

Chemical Name:

Heptanedioic acid-1-(2-cyclopentylidenehydrazide)

Molecular Formula:

C12H20N2O3

Molecular Weight:

240.3

CAS Number

1136466-93-7

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Borowiak, M., Maehr, R., Chen, S., Chen, A. E., Tang, W., Fox, J. L., ... & Melton, D. A. (2009). Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells.Cell stem cell,4(4), 348-358.

Li, W., & Ding, S. (2010). Small molecules that modulate embryonic stem cell fate and somatic cell reprogramming.Trends in pharmacological sciences,31(1), 36-45.

Aguayo-Mazzucato, C., & Bonner-Weir, S. (2010). Stem cell therapy for type 1 diabetes mellitus.Nature Reviews Endocrinology,6(3), 139-148.

技术参数
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