Applications

FA

Synonyms:

TbetaR-I Inhibitor, LY364947, LY 364947, Transforming Growth Factor-beta Type I Receptor Kinase Inhibitor

Formulation:

Crystalline solid

Chemical Name:

4-(5-pyridin-2-yl-1H-pyrazol-4-yl)quinoline

Molecular Formula:

C₁₇H₁₂N₄

Molecular Weight:

272.3

CAS Number

396129-53-6

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

S Bansal, S., Celia, C., Ferrati, S., Zabre, E., Ferrari, M., Palapattu, G., & Grattoni, A. (2013). Validated RP-HPLC method for the simultaneous analysis of gemcitabine and LY-364947 in liposomal formulations.Current drug targets,14(9), 1061-1069.

Nassar, K., Tura, A., Lueke, J., Lueke, M., & Grisanti, S. (2012). The novel use of LY364947 (LY), a TGF-ß Type I receptor inhibitor, in prevention of proliferative vitreoretinopathy (PVR).Investigative Ophthalmology & Visual Science,53(14), 893-893.

Oka, M., Iwata, C., Suzuki, H. I., Kiyono, K., Morishita, Y., Watabe, T., ... & Miyazono, K. (2008). Inhibition of endogenous TGF-β signaling enhances lymphangiogenesis.Blood,111(9), 4571-4579.