Applications

FA

Synonyms:

SB-431542, CHEMBL440084, 3tzm, GTPL8216, FHYUGAJXYORMHI-UHFFFAOYSA-N

Formulation:

Crystalline solid

Chemical Name:

4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide

Molecular Formula:

C₂₂H₁₆N₄O₃

Molecular Weight:

384.4

CAS Number

301836-41-9

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Inman, G. J., Nicolás, F. J., Callahan, J. F., Harling, J. D., Gaster, L. M., Reith, A. D., ... & Hill, C. S. (2002). SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.Molecular pharmacology,62(1), 65-74.

Laping, N. J., Grygielko, E., Mathur, A., Butter, S., Bomberger, J., Tweed, C., ... & Olson, B. A. (2002). Inhibition of transforming growth factor (TGF)-β1–induced extracellular matrix with a novel inhibitor of the TGF-β type I receptor kinase activity: SB-431542.Molecular pharmacology,62(1), 58-64.

Halder, S. K., Beauchamp, R. D., & Datta, P. K. (2005). A specific inhibitor of TGF-β receptor kinase, SB-431542, as a potent antitumor agent for human cancers.Neoplasia,7(5), 509-521.