Applications

FA

Synonyms:

XAV-939, CHEMBL1086580, 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one

Formulation:

Crystalline solid

Chemical Name:

2-[4-(trifluoromethyl)phenyl]-1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one

Molecular Formula:

C₁₄H₁₁F₃N₂OS

Molecular Weight:

312.3

CAS Number

284028-89-3

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Maroof, A. M., Keros, S., Tyson, J. A., Ying, S. W., Ganat, Y. M., Merkle, F. T., ... & Studer, L. (2013). Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells.Cell stem cell,12(5), 559-572.

Tian, X. H., Hou, W. J., Fang, Y., Fan, J., Tong, H., Bai, S. L., ... & Li, Y. (2013). XAV939, a tankyrase 1 inhibitior, promotes cell apoptosis in neuroblastoma cell lines by inhibiting Wnt/β-catenin signaling pathway.J Exp Clin Cancer Res,32(100), 9966-32.

Liu, C., & He, X. (2010). Destruction of a destructor: a new avenue for cancer therapeutics targeting the Wnt pathway.Journal of molecular cell biology,2(2), 70-73.