Recombinant Human IGF-BP3
货号：100-08-100,100-08-1000,100-08-25,100-08-250,100-08-5,100-08-500
规格：100ug,1mg,25ug,250ug,5ug,500ug
价格：6404,25699,1425,11216,585,16669
产品类型：细胞因子添加物
品牌：PeproTech
| 别名:Insulin-like Growth Factor-Binding Protein 3, Growth-hormone-dependent binding protein描述:IGF-BP3 is a 30 kDa, cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals, and it is also found in α-granules of platelets. In addition to its ability to modulate the activity of IGF-I and IGF-II, IGF-BP3 exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors, such as Bombesin, Vasopressin, PDGF, and EGF. Recombinant Human IGF-BP3 is a 28.8 kDa protein consisting of 264 amino acid residues.氨基酸序列:GASSGGLGPV VRCEPCDARA LAQCAPPPAV CAELVREPGC GCCLTCALSE GQPCGIYTER CGSGLRCQPS PDEARPLQAL LDGRGLCVNA SAVSRLRAYL LPAPPAPGNA SESEEDRSAG EVESPSVSST HRVSDPKFHP LHSKIIIIKK GHAKDSQRYK VDYESQSTDT QNFSSESKRE TEYGPCRREM EDTLNHLKFL NVLSPRGVHI PNCDKKGFYK KKQCRPSKGR KRGFCWCVDK YGQPLPGYTT KGKEDVHCYS MQSK来源:E.coli纯度:Greater than 98% by SDS-PAGE gel and HPLC analyses.生物活性:TheED50was determined by its ability to inhibit IGF-II induced proliferation of MCF-7. The expectedED50for this effect is ≤ 0.2 µg/ml in presence of 15 ng/ml of human IGF-II.交叉反应:Human原产国:USA仅用于研究。不适用于诊断或治疗。 |
product.subtitle.recentcitations |
第一作者 | Navarro, R |
标题 | TGF-β-induced IGFBP-3 is a key paracrine factor from activated pericytes that promotes colorectal cancer cell migration and invasion. |
文献引用 | Molecular Oncology; 14(10) pg2609-2628 |
PubMed Id | 32767843 |
第一作者 | Yamada, K |
标题 | Cell surface localization of importin α1/KPNA2 affects cancer cell proliferation by regulating FGF1 signalling. |
文献引用 | Scientific Reports; 6 pg21410 |
PubMed Id | 26887791 |
第一作者 | Martino, M M |
标题 | Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix. |
文献引用 | Proceedings of the National Academy of Sciences of the United States of America; 110(12) pg4563-8 |
PubMed Id | 23487783 |
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