Recombinant Human VEGF-B
货号：100-20B-100,100-20B-1000,100-20B-20,100-20B-250,100-20B-5,100-20B-500
规格：100ug,1mg,20ug,250ug,5ug,500ug
价格：9126,36565,1560,15974,640,23727
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述:VEGF-B, a member of the VEGF family, is a potent growth and angiogenic cytokine. It promotes DNA synthesis in endothelial cells, helps regulate angiogenesis and vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. VEGF-B is expressed in all tissues except the liver. It forms cell surface-associated, disulfide-linked homodimers, and can form heterodimers with VEGF-A. There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B167 and VEGF-B186. Both forms have identical amino-terminal sequences encoding a cysteine knot-like structural motif, but differ in their carboxyl-terminal domains. Both VEGF-B isoforms signal only through the VEGFR1 receptor. Recombinant Human VEGF-B is a 38.0 kDa, disulfide-linked homodimeric protein consisting of two 167 amino acid polypeptide chains.别名:Vascular Endothelial Growth Factor-B, VEGF-related factor, VRF氨基酸序列:PVSQPDAPGH QRKVVSWIDV YTRATCQPRE VVVPLTVELM GTVAKQLVPS CVTVQRCGGC CPDDGLECVP TGQHQVRMQI LMIRYPSSQL GEMSLEEHSQ CECRPKKKDS AVKPDSPRPL CPRCTQHHQR PDPRTCRCRC RRRSFLRCQG RGLELNPDTC RCRKLRR来源:E.coli纯度:Greater than 98% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) in the presence of human VEGF165. The expectedED50for this effect is 1.0-2.0 μg/ml.Calculated Molecular Weight:38 kDaAccession Number:P49765Gene ID:7423交叉反应: 人、大鼠原产地:USA仅用于科研，不能用于临床和诊断。 |
product.subtitle.recentcitations |
第一作者 | Zhang, L |
标题 | Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer. |
文献引用 | Cell; 181(2) pg442-459.e29 |
PubMed Id | 32302573 |
第一作者 | Huang, D |
标题 | VEGF-B inhibits hyperglycemia- and Macugen-induced retinal apoptosis. |
文献引用 | Scientific Reports; 6 pg26059 |
PubMed Id | 27189805 |
第一作者 | Massena, S |
标题 | Identification and characterization of VEGF-A-responsive neutrophils expressing CD49d, VEGFR1, and CXCR4 in mice and humans. |
文献引用 | Blood; 126(17) pg2016-26 |
PubMed Id | 26286848 |
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