Recombinant Human Sonic Hedgehog (Shh)
货号：100-45-100,100-45-1000,100-45-25,100-45-250,100-45-5,100-45-500
规格：100ug,1mg,25ug,250ug,5ug,500ug
价格：5959,23867,1418,10425,582,15483
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：Members of the Hedgehog (Hh) family are highly conserved proteins that are widely represented throughout the animal kingdom. The three known mammalian Hh proteins, Sonic (Shh), Desert (Dhh) and Indian (Ihh), are structurally related, and share a high degree of amino acid sequence identity (e.g. Shh and Ihh are 93% identical). The biologically active form of each Hh molecule is obtained by autocatalytic cleavage of their precursor proteins, and each corresponds to approximately one half of the N-terminal portion of the precursor molecule. Although Hh proteins have unique expression patterns and distinct biological roles within their respective regions of secretion, they use the same signaling pathway and can be substituted for one another in experimental systems. RecombinantE. coli-derived Human Sonic Hedgehog is a 20.0 kDa protein consisting of 176 amino acid residues, including an N-terminal Ile-Val-Ile sequence substituted for the naturally occurring, chemically modified, Cys residue.来源:E.coli别名:Hhg-1氨基酸序列:IVIGPGRGFG KRRHPKKLTP LAYKQFIPNV AEKTLGASGR YEGKISRNSE RFKELTPNYN PDIIFKDEEN TGADRLMTQR CKDKLNALAI SVMNQWPGVK LRVTEGWDED GHHSEESLHY EGRALDITTS DRDRSKYGML ARLAVEAGFD WVYYESKAHI HCSVKAENSV AAKSGG纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by its ability to induce alkaline phosphatase production by C3H/10T1/2 (CCL-226) cells. The expectedED50for this effect is 0.8-1.0 μg/ml.Calculated Molecular Weight:20 kDaAccession Number:Q15465Gene ID:6469交叉反应:Human,Mouse原产国:USA |
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