Recombinant Human sFas Receptor
货号：310-20-100,310-20-1000,310-20-20,310-20-250,310-20-5,310-20-500
规格：100ug,1mg,20ug,250ug,5ug,500ug
价格：8337,33403,1425,14593,585,21676
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：Fas and Fas Ligand (FasL) belong to the TNF superfamily, and are type I and type II transmembrane proteins, respectively. Binding of FasL to Fas triggers apoptosis in Fas-bearing cells. The mechanism of apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD, followed by processing of the pro-enzyme into active forms. These active caspases then cleave various cellular substrates, leading to the eventual cell death. sFasR is capable of inhibiting FasL-induced apoptosis by acting as a decoy receptor that serves as a sink for FasL. The full length Fas (receptor) is a 319 amino acid type I transmembrane protein, which contains a 157 amino acid extracellular domain, a 17 amino acid transmembrane domain, and a 145 amino acid cytoplasmic domain. Recombinant Human soluble Fas (sFas Receptor) is a 157 amino acid polypeptide (17.6 kDa) corresponding to the TNFR-homologous cysteine-rich extracellular Fas domain.来源:E.coli别名:soluble Fas receptor (sFasR), TNFRSF6, CD95, Apo I, Fas Antigen氨基酸序列:MRLSSKSVNA QVTDINSKGL ELRKTVTTVE TQNLEGLHHD GQFCHKPCPP GERKARDCTV NGDEPDCVPC QEGKEYTDKA HFSSKCRRCR LCDEGHGLEV EINCTRTQNT KCRCKPNFFC NSTVCEHCDP CTKCEHGIIK ECTLTSNTKC KEEGSRS纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:TheED50was determined by its ability to inhibit the cytotoxicity of Jurkat cells is between 10-15 µg/ml in the presence of 2ng/ml of hFasL.Calculated Molecular Weight:17.6 kDaAccession Number:P25445Gene ID:355交叉反应：原产国:USA |
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