货号：02913-60-50,02913-60-100,02913-60-200

规格：50 μg,100 μg,200 μg

价格：1210,2200,3520

产品类型：流式抗体

品牌：Biogems

物种：人

宿主：小鼠

抗体亚型：IgG

荧光染料：Purified

Catalogue Number : 02913-60

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The 3H5 monoclonal antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.

The 3H5 antibody block the binding of CD80 to its ligands.

Rat LPS-stimulated splenocytes were stained with PE 3H5 with autofluorescent cells in green.