ANTI-HUMAN CD38 (HIT2) APC

2024-10-17

ANTI-HUMAN CD38 (HIT2) APC

货号:17-0389-41,17-0389-42

规格:25TESTS,100TESTS

价格:1112,2629

产品类型:流式抗体

品牌:eBioscience

抗原:CD38

物种:人

宿主:小鼠

抗体亚型:IgG

克隆号:HIT2

荧光染料:APC

抗体类型:单抗同型对照:IgG1, kappa
免疫原性:用法:5uL(0.25 µg)/test(Flow)
Description: The HIT2 monoclonal antibody reacts with the human CD38 molecule, an approximately 45 kDa type II transmembrane protein. CD38 is expressed by thymocytes, peripheral B cells including plasma cells, activated T cells, and monocytes. CD38 is a counter-receptor for CD31 and has both cyclase and hydrolase enzymatic activity.Applications Reported: This HIT2 antibody has been reported for use in flow cytometric analysis.Applications Tested: This HIT2 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.25 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.Filtration: 0.2 µm post-manufacturing filtered.
数据

CD38 Antibody (17-0389-41) in FlowStaining of normal human peripheral blood cells with Mouse IgG1 K Isotype Control APC (Product # 17-4714-81) (blue histogram) or Anti-Human CD38 APC (purple histogram). Cells in the lymphocyte gate (left) and monocyte gate (right) were used for analysis.
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参考文献:
1.PloS oneRenal Transplant Recipients Treated with Calcineurin-Inhibitors Lack Circulating Immature Transitional CD19+CD24hiCD38hi Regulatory B-Lymphocytes."17-0389 was used in Flow cytometry/Cell sorting to analyse the effect of calcineurin inhibition on peripherally circulating regulatory B cells in renal transplant recipients receiving cyclosporine A or tacrolimus."Authors Tebbe B,Wilde B,Ye Z,Wang J,Wang X,Jian F,Dolff S,Schedlowski M,Hoyer PF,Kribben A,Witzke O,Hoerning A2.OncoimmunologyPD-L1 mediated the differentiation of tumor-infiltrating CD19+ B lymphocytes and T cells in Invasive breast cancer."17-0389 was used in Flow cytometry/Cell sorting to investigate the role of B cells in human breast cancer etiology."Authors Guan H,Lan Y,Wan Y,Wang Q,Wang C,Xu L,Chen Y,Liu W,Zhang X,Li Y,Gu Y,Wang Z,Xie F3.Nature communicationsSF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment."17-0389 was used in Flow cytometry/Cell sorting to demonstrate that mutations to SF3B1 can arise from CD34(+)CD38(-)CD45RA(-)CD90(+)CD49f(+) haematopoietic stem cells and is an initiating event in myelodysplastic syndrome patients."Authors Mian SA,Rouault-Pierre K,Smith AE,Seidl T,Pizzitola I,Kizilors A,Kulasekararaj AG,Bonnet D,Mufti GJ4.Journal of the American Society of Nephrology : JASNImmunologic human renal allograft injury associates with an altered IL-10/TNF-α expression ratio in regulatory B cells."17-0389 was used in Flow cytometry/Cell sorting to explore proinflammatory cytokine expression in B-cell subsets."Authors Cherukuri A,Rothstein DM,Clark B,Carter CR,Davison A,Hernandez-Fuentes M,Hewitt E,Salama AD,Baker RJ5.Genome researchDNA methylation profiling in human B cells reveals immune regulatory elements and epigenetic plasticity at Alu elements during B-cell activation."17-0389 was used in Flow cytometry/Cell sorting to investigate the profile of B-lymphocyte subsets during different stages of the humoral immune response in humans."Authors Lai AY,Mav D,Shah R,Grimm SA,Phadke D,Hatzi K,Melnick A,Geigerman C,Sobol SE,Jaye DL,Wade PA

技术参数

产品应用 Flow

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