CD44var (v6) Monoclonal Antibody (VFF-7), eBioscience™
货号：BMS116
规格：100 µg
价格：2037
产品类型：流式抗体
品牌：eBioscience
抗原：CD44var
物种：人
宿主：小鼠
抗体亚型：IgG
克隆号：VFF-7
荧光染料：其它
Description: Specifically recognizes an epitope encoded by exon v6 on the variant portion of human CD44.Standard CD44 (CD44s) lacks the entire variable region and is found mainly in cells of lymphohematopoietic origin. The multiple isoforms (designated CD44v; v = variant) contain alternatively spliced exons inserted within the extracellular domain. These isoforms are known as CD44v1, CD44v2, CD44v3, CD44v4, CD44v5, CD44v6, CD44v7, CD44v8, CD44v9, CD44v10, CD44v11.Applications Tested: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blotting.Purity: >95%.Background/Target InformationCD44 cell surface antigen is a 100kDa glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential.For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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| 参考文献： |
| 1.Journal of immunology (Baltimore, Md. : 1950)Monocytes."BMS116 was used in Flow cytometry/Cell sorting to investigate the mechanism of action underlying the tolerogenic function of soluble CD83."Authors Horvatinovich JM,Grogan EW,Norris M,Steinkasserer A,Lemos H,Mellor AL,Tcherepanova IY,Nicolette CA,DeBenedette MA2.American journal of physiology. Lung cellular and molecular physiologyErythropoietin-driven proliferation of cells with mutations in the tumor suppressor gene TSC2."BMS116 was used in flow cytometry to assess the effects of erythropoietin in human cells with loss of tuberin function"Authors Ikeda Y,Taveira-DaSilva AM,Pacheco-Rodriguez G,Steagall WK,El-Chemaly S,Gochuico BR,May RM,Hathaway OM,Li S,Wang JA,Darling TN,Stylianou M,Moss J |
技术参数 产品应用 Flow；IHC (P)；WB
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