P-cadherin Monoclonal Antibody (6A9)

货号：MA1-2003

规格：100 µg

价格：4963

产品类型：流式抗体

品牌：Thermo Fisher

物种：人/小鼠

宿主：小鼠

抗体亚型：其它

荧光染料：其它

类型:	单抗	同型对照：	IgG1
免疫原性：	A431 trypsinized membranes.	用法：	10 µg/mL(ICC);10 µg/mL(IF);1:100-1000(WB)

Product Specific InformationMA1-2003 detects P-cadherin from human and mouse samples.MA1-2003 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~120 kDa protein representing P-cadherin from A431 cell extract. MA1-2003 can also be used in immunoprecipitation and immunofluorescence procedures.The MA1-2003 immunogen is A431 trypsinized membranes.Target InformationP-cadherin, also known as Cadherin-3, is a Type 1 cadherin protein that belongs to the cadherin superfamily. Type 1 cadherins are single-pass transmembrane proteins that have 5 extracellular cadherin repeats and an intracellular domain that binds p120-catenin and beta-catenin. Cadherins are calcium-dependent cell-cell adhesion glycoproteins responsible for a range of processes including development, wound healing, cell-cell signaling, cell growth and differentiation. P-cadherin is expressed in human fetal structures, and in adult tissues such as the basal layer of the epidermis, breast, prostate, ovary, cervix, hair follicle, and corneal endothelium. P-cadherin expression has also been reported on embryonic stem cells, and stem cells of the normal mammary gland, and hair follicle. Overexpression of P-cadherin has been associated with poor prognosis in breast, prostate, ovary, colon, and stomach carcinomas. Mutations in CDH3 are associated with congential hypotrichosis with juvenile macular dystrophy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

数据

P-cadherin Antibody (MA1-2003) in IFImmunofluorescent analysis of placental Cadherin using Cadherin P Monoclonal Antibody (6A9) (Product # MA1-2003) shows staining in A2058 Cells. Cadherin P (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with an antibody recognizing Cadherin P (Product # MA1-2003) at a dilution of 1:20 over night at 4 °C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody (Product # 35552 for GAR, Product # 35503 for GAM). Images were taken at 60X magnification.

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参考文献：

1.Developmental biologyConnexins, E-cadherin, Claudin-7 and β-catenin transiently form junctional nexuses during the post-natal mammary gland development."MA1-2003 was used in western blot to assess the transiently formed junctional nexuses during post-natal mammary gland development by E-cadherins, connexins, beta-catenin, and claudin-7"AuthorsDianati E,Poiraud J,Weber-Ouellette A,Plante I2.Journal of cell scienceMechanism of extracellular domain-deleted dominant negative cadherins."MA1-2003 was used in western blot to investigate the functions of extracellular domain-deleted dominant-negative cadherin in cells"AuthorsNieman MT,Kim JB,Johnson KR,Wheelock MJ3.Journal of cell scienceInhibition of cadherin function differentially affects markers of terminal differentiation in cultured human keratinocytes. "MA1-2003 was used in blocking/activating experiment to investigate the effect of inhibition of cadherin function on keratinocyte differentiation" AuthorsHines MD,Jin HC,Wheelock MJ,Jensen PJ

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