SOX1 Polyclonal Antibody
货号：PA5-23351
规格：100 µg
价格：5548
产品类型：免疫组化一抗
品牌：eBioscience
物种：人/小鼠/大鼠
宿主：兔
抗体亚型：IgG
荧光染料：Purified
类型: | 多抗 | 同型对照： | |
浓度： | 0.5 mg/mL | 用法： | 5 µg/mL（IHC (P)）；1-4 µg/mL(WB) |
免疫原性： | Synthetic peptide (103 ALHMKEHPDYKYRPRR 118) of SOX1 protein |
靶标信息SOX1, also known as SRY (sex determining region Y)-box 1, is a transcription factor belonging to the SRY-related HMG box family of transcription factors with a HMG box DNA-binding domain. SOX1 works through multiple independent pathways to promote neuronal cell fate determination and differentiation. This nuclear protein acts as a modulator of LINE retroposons promoter activity and is also involved in the development of the central nervous system, mainly neural and lens development. Transcriptional activator SOX1 binds directly to the HES1 promoter and suppresses HES1 transcription, thus attenuating Notch signaling. It also binds to beta-catenin and suppresses beta-catenin-mediated TCF/LEF signaling, thus potentially attenuating the WNT signaling pathway. Expression of SOX1 is seen mostly in embryonic tissues and moderately in brain.
数据 |
| SOX1 Antibody (PA5-23351) in IHC (P) Immunohistochemical analysis of SOX1 in formalin-fixed, paraffin-embedded human brain tissue using an isotype control (top) and a SOX1 polyclonal antibody (Product # PA5-23351) (bottom) at 5 µg/mL. |
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| 二抗荧光二抗免疫组化一抗标签抗体 |
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QQ:1749072012