CD9 Monoclonal Antibody (MM2/57)/CD9 单克隆抗体 (MM2/57)

货号：AHS0902

规格：100 µg

价格：2910

产品类型：流式抗体

品牌：eBioscience

抗原：Human platelet glycoprotein

物种：人

宿主：小鼠

抗体亚型：IgG2b, kappa

克隆号：MM2/57

荧光染料：其它

类型:	二抗	同型对照：
浓度：	0.5 mg/mL	用法：	(ICC);(IF);(WB)

靶标信息CD9 antigen is a glycoprotein expressed on the surface of developing B lymphocytes, platelets, monocytes, eosinophils, basophil, stimulated T lymphocytes and by neurons and glial cells in the peripheral nervous system. CD9 belongs to a family of membrane proteins termed tetraspanins which transverse the membrane four times. In pre B cells and platelets, CD9 antigen regulates cell activation and aggregation possibly through an association with the integrin CD41 / CD61 (GPIIb / GPIIIa). CD9 is involved in cell motility, osteoclastogenesis, neurite outgrowth, myotube formation, and sperm-egg fusion, plays roles in cell attachment and proliferation and is necessary for association of heterologous MHC II molecules on the dendritic cell plasma membrane which is important for effective T cell stimulation. CD9 functions in many cellular processes including differentiation, adhesion, and signal transduction, and expression plays a critical role in the suppression of cancer cell motility and metastasis. CD9 is also considered as metastasis suppressor in solid tumors.

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参考文献：

1.Methods in molecular biology (Clifton, N.J.) Self-Replicating RNA Vaccine Delivery to Dendritic Cells. 2.Oncotarget CD151-α3β1 integrin complexes are prognostic markers of glioblastoma and cooperate with EGFR to drive tumor cell motility and invasion. 3.Cancer research Cell surface tetraspanin CD9 mediates chemoresistance in small cell lung cancer. 4.The Journal of biological chemistry Double deficiency of tetraspanins CD9 and CD81 alters cell motility and protease production of macrophages and causes chronic obstructive pulmonary disease-like phenotype in mice. 5.Thrombosis and haemostasis CD63 modulates spreading and tyrosine phosphorylation of platelets on immobilized fibrinogen.

技术参数

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