CD9 Monoclonal Antibody (MEM-61), Alexa Fluor 647/CD9 单抗 (MEM-61), Alexa Fluor 647

2024-10-17

CD9 Monoclonal Antibody (MEM-61), Alexa Fluor 647/CD9 单抗 (MEM-61), Alexa Fluor 647

货号:MA5-18154

规格:100 tests

价格:4733

产品类型:流式抗体

品牌:Thermo Fisher

抗原:Pre-B cell line NALM-6

物种:人

宿主:小鼠

抗体亚型:其它

克隆号:MEM-61

荧光染料:Alexa Fluor 647

类型:

单抗

同型对照:

IgG1

浓度:

用法:

4 µLx100 µL whole blood or 10^6 cells(Flow);(WB)

产品详细信息This antibody recognizes an epitope on second extracellular domain (EC2) of CD9 antigen.靶标信息CD9 antigen is a glycoprotein expressed on the surface of developing B lymphocytes, platelets, monocytes, eosinophils, basophil, stimulated T lymphocytes and by neurons and glial cells in the peripheral nervous system. CD9 belongs to a family of membrane proteins termed tetraspanins which transverse the membrane four times. In pre B cells and platelets, CD9 antigen regulates cell activation and aggregation possibly through an association with the integrin CD41 / CD61 (GPIIb / GPIIIa). CD9 is involved in cell motility, osteoclastogenesis, neurite outgrowth, myotube formation, and sperm-egg fusion, plays roles in cell attachment and proliferation and is necessary for association of heterologous MHC II molecules on the dendritic cell plasma membrane which is important for effective T cell stimulation. CD9 functions in many cellular processes including differentiation, adhesion, and signal transduction, and expression plays a critical role in the suppression of cancer cell motility and metastasis. CD9 is also considered as metastasis suppressor in solid tumors.

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