Rat IgM Isotype Control/大鼠IgM同型对照
货号：02-9888
规格：500 µg
价格：2310
产品类型：大鼠同型对照
品牌：Thermo Fisher
抗原：Rat IgM
物种：其它
宿主：大鼠
抗体亚型：IgM
荧光染料：其它
| 类型: | | 同型对照： | |
| 浓度： | 1 mg/mL | 用法： | Assay-Dependent(对照试剂（Ctrl));Assay-Dependent(Flow) |
| 靶标信息Immunoglobulin M is the third most common serum Ig and can exist as pentamer where all heavy chains are identical and all light chains are identical or as a monomer (e.g. found on B lymphocytes as B - cell receptors). The large pentameric structure allows for building of bridges between encountered epitopes on molecules that are too distant as to be connected by smaller IgG antibodies. IgM is built as the first antibody during an immune response and is responsible for agglutination and cytolytic reactions since its pentameric structure gives it 10 free antigen binding sites in theory and it posseses a high avidity. Due to conformational constraints among the 10 Fab portions, IgM only has a valence of 5. Additionally, IgM is not as versatile as IgG, but it is of vital importance in complement activation and agglutination. IgM is predominantly found in the lymph fluid and the blood and is a very effective neutralizing agent in the early stages of disease. Elevated levels can be a sign of recent infection or exposure to antigen. |
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| 参考文献： |
| 1.Journal of immunology (Baltimore, Md. : 1950) An immunoregulatory role for neutrophils in CD4+ T helper subset selection in mice with candidiasis. 2.Journal of immunology (Baltimore, Md. : 1950) Gamma delta T cells in normal spleen assist immunized alpha beta T cells in the adoptive cell transfer of contact sensitivity. Effect of Bordetella pertussis, cyclophosphamide, and antibodies to determinants on suppressor cells. 3.Journal of immunology (Baltimore, Md. : 1950) Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype. 4.Journal of immunology (Baltimore, Md. : 1950) Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype. |
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