CD4 Monoclonal Antibody (OKT4 (OKT-4)), FITC, eBioscience™
货号：11-0048-41,11-0048-42
规格：25 tests,100 tests
价格：807,1822
产品类型：流式抗体
品牌：Thermo Fisher
抗原：CD4
物种：人
宿主：小鼠
抗体亚型：IgG2b, kappa
克隆号：OKT4 (OKT-4)
荧光染料：FITC
| 抗体类型: | 流式抗体 | 同型对照： | Mouse IgG2b kappa Isotype Control (eBMG2b), FITC, eBioscience™ |
| 浓度： | 5 µL/Test | 用法： | 5 µL (0.25 µg)/test (Flow） |
| 产品详细信息Description: The OKT4 monoclonal antibody reacts with human CD4, a 59 kDa cell surface glycoprotein expressed by the majority of thymocytes, a subpopulation of mature T cells (T-helper cells) and in low levels on monocytes. CD4 is a receptor for the human immunodeficiency virus (HIV). The OKT4 antibody recognizes a different epitope than the RPA-T4 monoclonal antibody, and these antibodies do not cross-block binding to each other's respective epitopes.Applications Reported: This OKT4 (OKT-4) antibody has been reported for use in flow cytometric analysis.Applications Tested: This OKT4 (OKT-4) antibody is offered in 2 formats: - µg size: has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. - test size: has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.25 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.Filtration: 0.2 µm post-manufacturing filtered. 靶标信息The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017]. |
| 数据 |
CD4 Antibody (11-0048-41) in Flow Staining of normal human peripheral blood cells with Anti-Human CD4 FITC followed by intracellular staining with Anti-Human Foxp3 PE (Product # 12-4776-42) using the Foxp3 Staining Buffers (Product # 00-5523-00). Cells in the lymphocyte gate were used for analysis.CD4 Antibody (11-0048-41) PloS one 2015 -Figure 3 IHC analysis of paraffin-embedded tumor sections from patients with PDA or control pancreatic tissue. Magnification: 200x. Comparisons of FoxP3 + cell, CD8 + cell and CD4 + cell infiltrates between the juxtatumoral stroma and the panstroma. IHC analyzed the expression of Foxp3, CD4 and CD8 and statistical analysis the frequencies in juxtatumoral stroma and in panstroma. Comparisons between the two groups were assessed using Student and apos;s t test. NS, not significant; ** P <0.01, *** P <0.001. |
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| 参考文献： |
| 1.Molecular medicine reports Umbilical cord blood‑derived Helios‑positive regulatory Tcells promote angiogenesis in acute lymphoblastic leukemia in mice via CCL22 and the VEGFA‑VEGFR2 pathway. 2.Nature communicationsComplement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism. 3.Oncology lettersAccumulation of T-helper 22 cells, interleukin-22 and myeloid-derived suppressor cells promotes gastric cancer progression in elderly patients. 4.Nature communicationsIL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells. 5.Nature communicationsClinically compliant spatial and temporal imaging of chimeric antigen receptor T-cells. |
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