Cytochrome C Monoclonal Antibody (2B5), eBioscience/细胞色素C单克隆抗体（2B5）
货号：BMS1037
规格：100 µg
价格：3679
产品类型：流式抗体
品牌：eBioscience
物种：人
宿主：小鼠
抗体亚型：其它
克隆号：2B5
荧光染料：其它
类型: | 单抗 | 同型对照： | |
浓度： | 1 mg/mL | 用法： | Assay-Dependent（ELISA)；Assay-Dependent(Flow)；Assay-Dependent(IP)；Assay-Dependent(WB) |
产品详细信息Description: Cytochrome c was identified as a component required for the crucial steps in apoptosis, caspase-3 activation and DNA fragmentation. Cytochrome c was shown to redistribute from mitochondria to cytosol during apoptosis in intact cells.Mitochrondrial cytochrome c is a water-soluble protein of 15 kDa with a net positive charge, residing loosely attached in the mitochrondrial intermembrane space. Cytochrome c functions in the respiratory chain by interaction with redox partners.The release of cytochrome c into the cytosol leads to an activation of an apoptotic program via activation of a caspase dependent pathway. Cytochrome c achieves this goal by interaction with other cytosolic factors forming a complex (apoptosome) composed of cytochrome c, Apaf-1, dATP and Apaf-3/caspase 9. Bcl-2 on the other hand was shown to be able to prevent apoptosis by blocking the release of cytochrome c from mitochondria.Applications Tested: ELISA, Flow Cytometry, Western Blotting.靶标信息Cytochrome C is an electron transporting protein that resides within the intermembrane space of the mitochondria, where it plays a critical role in oxidative phosphorylation and the production of cellular ATP. Release of cytochrome C from the mitochondria to the cytosol is triggered by apoptotic stimuli. In the cytoplasm, the cytochrome C binds apoptotic protease activating factor which activates the apoptotic initiator procaspase 9. Cytosolic cytochrome C functions in the activation of caspase3, an ICE family molecule that is a key effector of apoptosis.
流式抗体
QQ:1749072012