Human Presenilin 1 ELISA Kit/人Presenilin 1 ELISA试剂盒
货号：EH380RB,EH380RBX5,EH380RBX10
规格：96 tests,5X96 tests,10X96 tests
价格：6327,28472,54564
产品类型：Platinum ELISA
品牌：Thermo Fisher
物种：人
宿主：其它
抗体亚型：其它
荧光染料：其它
灵敏度 | 10.5 pg/mL |
| 检测范围 | 10.5-2,500 pg/mL |
样本类型/体积 | 血清 50 μL 血浆 50 μL 上清液 50 μL |
操作时间 | 1 hr 20 min |
测试时间 | 4 hr 45 min |
Homogenous (no wash) | No |
| 批间变异系数（CV） | <12% |
| 批内变异系数（CV） | <10% |
仪器设备 | Colorimetric Microplate Reader 酶标仪 |
规格 | 5 x 96 Tests |
组份 | - 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖 |
储存温度 | 2-8℃ |
| Protein name | Presenilin 1 |
| Protein aliases | Presenilin-1, Presenilin-1 CTF subunit, Presenilin-1 CTF12, Presenilin-1 NTF subunit, Protein S182, PS-1, PS1-CTF12 |
物种（Tested） | 人 |
试剂盒类型 | Sandwich ELISA Kit |
标记（染料） | HRP |
| 检测抗体偶联物 | Biotin |
| Gene aliases | AD3, FAD, PS-1, PS1, PSEN1, PSNL1, S182 |
| Gene ID | (Human) 5663 |
| Gene symbol | PSEN1 |
| UniProt ID | (Human) P49768 |
| Human Presenilin 1 quantitates human Presenilin 1 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Presenilin 1.人早Presenilin1定量测定血清，血浆，上清液中的人Presenilin1。该检测试剂盒将专门识别天然和重组人Presenilin 1。Target information 靶标信息Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer's disease. In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the -gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, -gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and -gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and -gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer's disease. Multiple isoforms of presenilin1 are known to exist.Presenilin1最初被确定为对早发性阿尔茨海默氏病的易感性标志物。除PEN2，尼卡斯汀和APH-1外，Presenilin1还形成了-γ-分泌酶蛋白复合物，这是一种膜结合的天冬氨酰蛋白酶，可以在脂质双层疏水环境中的肽键处裂解某些蛋白质。这种切割是从几个细胞表面受体发出信号的关键步骤，并且被认为是神经毒性淀粉样肽生成所必需的，而神经毒性淀粉样肽是阿尔茨海默氏病发病机理的核心。像肿瘤坏死因子-α转换酶（TACE）和β-位点切割酶（BACE）蛋白酶家族一样，-γ-分泌酶将切割淀粉样前体蛋白（APP），但在APP的膜内区域内，导致无毒的p3（来自α和-γ切割位点）或有毒的Abeta淀粉样肽（来自β和-γ切割位点）。认为Aβ肽的积累是阿尔茨海默氏病的前体。Presenilin1的多种同工型已知存在。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。 |
©
Bio-Rad伯乐代理官网-伯乐抗体-伯乐层析Aminex色谱柱是专业的授权总代理区域代理经销平台。
© 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
© 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
© 本文地址：
https://www.biorod.cn/thread-24657.htm
QQ:1749072012