Human Integrin alpha-M/CD11b/MAC-1 ELISA Kit/人整合素alpha-M / CD11b / MAC-1 ELISA试剂盒
货号：EH279RB,EH279RBX5,EH279RBX10
规格：96 Tests,5X96 Tests,10X96 tests
价格：6641,29884,57271
产品类型：Platinum ELISA
品牌：Thermo Fisher
物种：人
宿主：其它
抗体亚型：其它
荧光染料：其它
灵敏度 | 2.5 ng/mL |
| 检测范围 | 2.5-600 ng/mL |
样本类型/体积 | 血清 50 μL 血浆 50 μL 上清液 50 μL |
操作时间 | 1 hr 20 min |
测试时间 | 4 hr 45 min |
Homogenous (no wash) | No |
| 批间变异系数（CV） | <12% |
| 批内变异系数（CV） | <10% |
仪器设备 | Colorimetric Microplate Reader 酶标仪 |
规格 | 5 x 96 Tests |
组份 | - 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖 |
储存温度 | 2-8℃ |
| Protein name | CD11b |
| Protein aliases | antigen CD11b (p170), CD11 antigen-like family member B, CD11b, Cell surface glycoprotein MAC-1 subunit alpha, complement component 3 receptor 3 subunit, CR-3 alpha chain, Integrin alpha-M, integrin, alpha M (complement component 3 receptor 3 subunit), Leukocyte adhesion receptor MO1, macrophage antigen alpha polypeptide, Neutrophil adherence receptor, neutrophil adherence receptor alpha-M subunit |
物种（Tested） | 人 |
试剂盒类型 | Sandwich ELISA Kit |
标记（染料） | HRP |
| 检测抗体偶联物 | Biotin |
| Gene aliases | CD11B, CR3A, ITGAM, MAC-1, MAC1A, MO1A, SLEB6 |
| Gene ID | (Human) 3684 |
| Gene symbol | ITGAM |
| UniProt ID | (Human) P11215 |
| Human Integrin alpha-M/CD11b/MAC-1 quantitates human Integrin alpha-M/CD11b/MAC-1 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Integrin alpha-M/CD11b/MAC-1.人整联蛋白α-M/ CD11b / MAC-1定量测定血清，血浆，上清液中的人整联蛋白α-M/ CD11b / MAC-1。该检测试剂盒将专门识别天然和重组人整联蛋白α-M/ CD11b / MAC-1。Target information 靶标信息CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). CD11b is expressed on the surface of monocytes/macrophages, granulocytes, activated lymphocytes, a subset of NK cells, a subset of dendritic cells, and microglia in the brain. CD11b/CD18 functions as the receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X -these adhesions are critical for cell-cell and cell-matrix interactions. CD11b is expressed on 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue. The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Further, peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages. Diseases associated with CD11b dysfunction include systemic lupus erythematosus 6 and ITGAM-related susceptibility to systemic lupus erythematosus.CD11b（整合素α-M，ITGAM，整合素α-X，ITGAX）是一个165 kDa的粘附分子，与整合素beta-2（CD18）非共价结合。 CD11b / CD18异二聚体复合物也称为整联蛋白α-Mbeta-2，Mac-1和CR3（补体受体3）。 CD11b在脑中的单核细胞/巨噬细胞，粒细胞，活化的淋巴细胞，NK细胞的一部分，树突状细胞的一部分和小胶质细胞的表面表达。 CD11b / CD18充当ICAM-1（CD54），ICAM-2（CD102），ICAM-4（CD242），CD14，CD50，CD23，肝素，iC3b，纤维蛋白原和X因子的受体-这些黏附对于细胞-细胞和细胞-基质相互作用。 CD11b在8％的脾细胞，44％的骨髓细胞和不到1％的胸腺细胞上表达，通常在神经组织中用作小胶质细胞标记物。 CD11b的表达在单核细胞成熟期间增加，并且表达水平在组织巨噬细胞上有所不同。此外，据报道腹膜巨噬细胞比脾巨噬细胞表达更高水平的CD11b。与CD11b功能障碍相关的疾病包括系统性红斑狼疮6和ITGAM相关的系统性红斑狼疮易感性。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。 |
©
Bio-Rad伯乐代理官网-伯乐抗体-伯乐层析Aminex色谱柱是专业的授权总代理区域代理经销平台。
© 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
© 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
© 本文地址：
https://www.biorod.cn/thread-24757.htm
QQ:1749072012