Rat P-Selectin ELISA Kit/大鼠P选择素ELISA试剂盒
货号：ERA51RB,ERA51RBX5
规格：96 Tests,5X96 Tests
价格：6641,29884
产品类型：Platinum ELISA
品牌：Thermo Fisher
物种：大鼠
宿主：其它
抗体亚型：其它
荧光染料：其它
灵敏度 | 40 pg/mL |
| 检测范围 | 40-10,000 pg/mL |
样本类型/体积 | 血清 50 μL 血浆 50 μL 上清液 50 μL |
操作时间 | 1 hr 20 min |
测试时间 | 4 hr 45 min |
Homogenous (no wash) | No |
| 批间变异系数（CV） | <12% |
| 批内变异系数（CV） | <10% |
仪器设备 | Colorimetric Microplate Reader 酶标仪 |
规格 | 5 x 96 Tests |
组份 | - 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖 |
储存温度 | 2-8℃ |
| Protein name | P-Selectin (CD62P) |
| Protein aliases | CD62 antigen-like family member P, CD62P, GMP-140, Granule membrane protein 140, LECAM3, Leukocyte-endothelial cell adhesion molecule 3, P-selectin, PADGEM, Platelet activation dependent granule-external membrane protein, selectin, platelet |
物种（Tested） | 大鼠 |
试剂盒类型 | Sandwich ELISA Kit |
标记（染料） | HRP |
| 检测抗体偶联物 | Biotin |
| Gene aliases | PSELECT, Selp |
| Gene ID | (Rat) 25651 |
| Gene symbol | Selp |
| UniProt ID | (Rat) P98106 |
| Rat P-Selectin quantitates rat P-Selectin in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant rat P-Selectin.大鼠P-选择素定量测定血清，血浆，上清液中的大鼠P-选择素。该检测试剂盒将专门识别天然和重组大鼠P-选择素。Target information 靶标信息P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type 1 transmembrane glycoprotein, and is one of the most commonly studied proteins that regulate cell rolling. P-selectin is stored in the Weibel-Palade bodies of endothelial cells, as well as in a-granules of platelets. From there, it can be rapidly brought to the cell surface after exposure to thrombin, histamine, complement 5a, Ca21 ionophores, or adenosine diphosphate. P-selectin protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. P-selectin plays an important role in adhesive processes between leucocytes and endothelial cells, and is a calcium dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens found on neutrophils and monocytes. P-selectin is constitutively expressed in inflammation and contributes to atherogenesis, thrombosis and tissue destruction. Clinically, P-selectin is used to distinguish heparin induced thrombocytopenia with and without thrombosis.P-选择蛋白（Selectin P，GMP-140，LECAM3，CD62抗原样家族成员）是一个140 kDa的1型跨膜糖蛋白，是调节细胞滚动的最常研究的蛋白之一。 P-选择蛋白储存在内皮细胞的Weibel-Palade体以及血小板的a颗粒中。暴露于凝血酶，组胺，补体5a，Ca21离子载体或二磷酸腺苷后，可从那里迅速带入细胞表面。 P-选择蛋白蛋白在血小板活化和脱粒过程中重新分布到质膜，并介导活化的内皮细胞或血小板与白细胞的相互作用。 P-选择蛋白在白细胞和内皮细胞之间的黏附过程中起重要作用，并且是钙依赖性受体，可与中性粒细胞和单核细胞上发现的路易斯血型碳水化合物抗原的唾液酸化形式结合。 P-选择蛋白在炎症中组成性表达，并有助于动脉粥样硬化，血栓形成和组织破坏。在临床上，P-选择素用于区分肝素诱导的血小板减少症与有无血栓形成。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。 |
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