Mouse VISTA/B7-H5/PD-1H ELISA Kit/小鼠VISTA / B7-H5 / PD-1H ELISA试剂盒
货号：EM74RB,EM74RBX5,EM74RBX10
规格：96 Tests,5X96 Tests,10X96 tests
价格：6641,29884,57271
产品类型：Platinum ELISA
品牌：Thermo Fisher
物种：小鼠
宿主：其它
抗体亚型：其它
荧光染料：其它
灵敏度 | 3 ng/mL |
| 检测范围 | 3-600 ng/mL |
样本类型/体积 | 血清 50 μL 血浆 50 μL 上清液 50 μL |
操作时间 | 1 hr 20 min |
测试时间 | 4 hr 45 min |
Homogenous (no wash) | No |
| 批间变异系数（CV） | <12% |
| 批内变异系数（CV） | <10% |
仪器设备 | Colorimetric Microplate Reader 酶标仪 |
规格 | 5 x 96 Tests |
组份 | - 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖 |
储存温度 | 2-8℃ |
| Protein name | VISTA |
| Protein aliases | differentiation of ESCs 1, Platelet receptor Gi24, V-set domain-containing immunoregulatory receptor, V-set immunoregulatory receptor, V-type immunoglobulin domain-containing suppressor of T-cell activation |
物种（Tested） | 小鼠 |
试剂盒类型 | Sandwich ELISA Kit |
标记（染料） | HRP |
| 检测抗体偶联物 | Biotin |
| Gene aliases | Dies1, PD-1H, VISTA, Vsir |
| Gene ID | (Mouse) 74048 |
| Gene symbol | 4632428N05Rik |
| UniProt ID | (Mouse) Q9D659 |
| Mouse VISTA/B7-H5/PD-1H quantitates mouse VISTA/B7-H5/PD-1H in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant mouse VISTA/B7-H5/PD-1H.小鼠VISTA / B7-H5 / PD-1H定量测定血清，血浆，上清液中的小鼠VISTA / B7-H5 / PD-1H。 该检测试剂盒将专门识别天然和重组小鼠VISTA / B7-H5 / PD-1H。Target information 靶标信息VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is a product of the VSIR gene. Although VISTA bears sequence homology to PD-L1 it has a different expression pattern. In both mouse and humans, VISTA is expressed predominantly on hematopoietic cells with the highest densities on myeloid cells, and lower levels on T cells. It is usually absent on B cells. VISTA expressed by antigen presenting cells has been shown to directly suppress proliferation and cytokine production of CD4 and CD8 T cells, making it a target for cancer immunotherapy. The reported ligands of VISTA include CD28H, VSIG-3 and VSIG-8.VISTA（含有T细胞活化抑制剂的V结构域Ig），也称为B7-H5或PD-1H，是VSIR基因的产物。 尽管VISTA与PD-L1具有序列同源性，但它具有不同的表达模式。 在小鼠和人中，VISTA主要在造血细胞上表达，其在髓样细胞上的密度最高，而在T细胞上的水平较低。 通常在B细胞上不存在。 抗原呈递细胞表达的VISTA已显示可直接抑制CD4和CD8 T细胞的增殖和细胞因子的产生，使其成为癌症免疫疗法的靶标。 报道的VISTA配体包括CD28H，VSIG-3和VSIG-8。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。 |
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