Lymphotoxin beta Receptor Monoclonal Antibody (eBio3C8 (3C8)), Functional Grade, eBioscience™/Lymphotoxin beta Receptor Monoclonal Antibody (eBio3C8 (3C8)), 功能抗体, eBioscience™
货号：16-5671-82,16-5671-38,16-5671-025,16-5671-050
规格：100 µg,5 mg,25 mg,50 mg
价格：3496,24089,72266,120443
产品类型：流式抗体
品牌：eBioscience
抗原：Lymphotoxin beta Receptor
物种：小鼠
宿主：大鼠
抗体亚型：IgG1, kappa
克隆号：eBio3C8 (3C8)
荧光染料：其它
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类型: | 一抗(功能抗体） | 同型对照： | Rat IgG1 kappa Isotype Control (eBRG1), Functional Grade, eBioscience™ |
浓度： | 1 mg/mL | 用法： | 0.5 µg/test（Flow） |
产品详细信息Description: The antibody reacts with mouse lymphotoxin-beta receptor (LTBR). Northern blot analysis of tissues from adult mice showed that expression levels of LTBR mRNA were strong in lung, liver, and kidney, moderate in heart and testes, but weak in brain, thymus, spleen, and lymph nodes. The tumor necrosis factor receptor-related protein is the human receptor for the heterotrimer of lymphotoxinalpha and lymphotoxin beta. This LT alpha/LTbeta heterotrimer (LT alpha 1/beta 2) is assumed to take part in immunologic reactions by cell-cell contact, but does not bind to either TNFR1 (CD120 alpha) or TNFR2 (CD120 beta). LTBR is expressed by day 7 embryos, so it has been speculated that the LT alpha/LT beta receptor system may also have some function in early embryogenesis.Applications Reported: This eBio3C8 (3C8) antibody has been reported for use in flow cytometric analysis and to have agonistic activity (via activation of NK kappa B).Applications Tested: This eBio3C8 (3C8) antibody has been tested by flow cytometric analysis of NIH/3T3 cells. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Storage and handling: Use in a sterile environment.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of the encodedprotein can trigger apoptosis.仅用于科研。不用于诊断过程。
数据 |
| Lymphotoxin beta Receptor Antibody (16-5671-82) in FlowStaining of NIH/3T3 cell line with 0.25 µg of Rat IgG1 Isotype Control Functional Grade Purified (Product # 16-4301-81) (open histogram) or 0.25 µg of Anti-Mouse Lymphotoxin beta Receptor Functional Grade Purified (filled histogram) followed by Anti-Rat IgG Biotin (Product # 13-4813-85) and Streptavidin PE (Product # 12-4317-87).Total viable cells were used for analysis. |
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参考文献： |
| 流式1.EMBO molecular medicineAdministration of RANKL boosts thymic regeneration upon bone marrow transplantation."16-5671 was used in Flow cytometry/Cell sorting to indicate that RANKL may be clinically useful to improve T-cell function recovery after bone marrow transplantation by controlling multiple facets of thymic regeneration."AuthorsLopes N,Vachon H,Marie J,Irla M2.Nature communicationsLymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells."Published figure using Lymphotoxin beta Receptor monoclonal antibody (Product # 16-5671-82) in Flow Cytometry"3.Nature communicationsTreg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration."Published figure using Lymphotoxin beta Receptor monoclonal antibody (Product # 16-5671-82) in Flow Cytometry"功能检测4.Cell reportsAn IKKα-nucleophosmin axis utilizes inflammatory signaling to promote genome integrity."16-5671 was used in Functional assays to study the mechanism by which cells are able to protect themselves from inflammatory signals which promote skin tumourigenesis."AuthorsXia X,Liu S,Xiao Z,Zhu F,Song NY,Zhou M,Liu B,Shen J,Nagashima K,Veenstra TD,Burkett S,Datla M,Willette-Brown J,Shen H,Hu Y5.Cancer cellA lymphotoxin-driven pathway to hepatocellular carcinoma.AuthorsHaybaeck J,Zeller N,Wolf MJ,Weber A,Wagner U,Kurrer MO,Bremer J,Iezzi G,Graf R,Clavien PA,Thimme R,Blum H,Nedospasov SA,Zatloukal K,Ramzan M,Ciesek S,Pietschmann T,Marche PN,Karin M,Kopf M,Browning JL,Aguzzi A,Heikenwalder M |
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