CD31 (PECAM-1) Monoclonal Antibody (390), Functional Grade, eBioscience™/CD31 (PECAM-1) 单克隆 (390), 功能抗体, eBioscience™

货号：16-0311-85,16-0311-38,16-0311-025,16-0311-050

规格：500 µg,5 mg,25 mg,50 mg

价格：3496,24089,72266,120443

产品类型：流式抗体

品牌：eBioscience

抗原：CD31

物种：小鼠

宿主：大鼠

抗体亚型：IgG2a, kappa

克隆号：390

荧光染料：其它

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类型:	一抗(功能抗体）	同型对照：	Rat IgG2a kappa Isotype Control (eBR2a), Functional Grade, eBioscience™
浓度：	1 mg/mL	用法：	0.5 µg/test（Flow）;Assay-Dependent（功能检测）

产品详细信息Description: The 390 monoclonal antibody reacts with mouse CD31, also known as platelet-endothelial cell adhesion molecule-1 (PECAM-1) and gpIIa. This 130-140 kDa surface protein is expressed by endothelial cells and at low levels on all leukocytes and platelets. It has been reported that CD38 binds to CD31. Homotypic interaction of CD31 is important in adhesion, cell-cell and cell-matrix interaction, and signal transduction.Applications Reported: The 390 antibody has been reported foruse in flow cytometric analysis. 390 has also been reported in in vitro functional studies.Applications Tested: The 390 antibody has been tested by flow cytometric analysis of mouse thymocytes and splenocytes. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Storage and handling: Use in a sterile environment.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.仅用于科研。不用于诊断过程。

数据

CD31 (PECAM-1) Antibody (16-0311-85) in FlowStaining of mouse splenocytes with Anti-Mouse CD31 (PECAM-1) FITC (left) or PE (right).Autofluorescence is shown via open histogram.Total viable cells were used for analysis.

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参考文献：

流式1.Journal of clinical and translational researchPlatelet aggregation but not activation and degranulation during the acute post-ischemic reperfusion phase in livers with no underlying disease."Published figure using CD31 (PECAM-1) monoclonal antibody (Product # 16-0311-85) in Immunofluorescence"2.Cellular and molecular gastroenterology and hepatologyIndian Hedgehog Suppresses a Stromal Cell-Driven Intestinal Immune Response."Published figure using CD31 (PECAM-1) monoclonal antibody (Product # 16-0311-85) in Flow Cytometry"3.Nature communicationsAdipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation."Published figure using CD31 (PECAM-1) monoclonal antibody (Product # 16-0311-85) in Flow Cytometry"IF4.Journal of clinical and translational researchPlatelet aggregation but not activation and degranulation during the acute post-ischemic reperfusion phase in livers with no underlying disease."Published figure using CD31 (PECAM-1) monoclonal antibody (Product # 16-0311-85) in Immunofluorescence"5.PloS oneLeukemia Inhibitory Factor Enhances Endogenous Cardiomyocyte Regeneration after Myocardial Infarction."Published figure using CD31 (PECAM-1) monoclonal antibody (Product # 16-0311-85) in Immunofluorescence"

技术参数

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