CD85k (ILT3) Monoclonal Antibody (ZM4.1), Functional Grade, eBioscience™/CD85k (ILT3) 单克隆 (ZM4.1), 功能抗体, eBioscience™
货号：16-5139-81,16-5139-85,16-5139-38,16-5139-025,16-5139-050
规格：50 µg,500 µg,5 mg,25 mg,50 mg
价格：1283,4324,24089,72266,120443
产品类型：流式抗体
品牌：eBioscience
抗原：CD85k
物种：人
宿主：小鼠
抗体亚型：IgG1, kappa
克隆号：ZM4.1
荧光染料：其它
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类型: | 一抗(功能抗体） | 同型对照： | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Functional Grade, eBioscience™ |
浓度： | 1 mg/mL | 用法： | 0.25 µg/test（Flow）；Assay-Dependent（功能检测）；Assay-Dependent（中和） |
产品详细信息Description: The monoclonal antibody ZM4.1 recognizes ILT3, also known as CD85k. ILT3 is a member of the large family of ILT molecules (Immunologulin-like Transcripts, Leucocyte Ig-like Receptors (LIRs) and Monocyte/Macrophage Ig-like Receptors (MIRs). ILT3 is a 60kDa transmembrane protein with two Ig domains and ITIMs. Expression is found on monocytes, macrophages, and dendritic cells. High levels of ILT3 expression is also found on plasmacytoid dendritic cells (pDCs). ILT3 expression by DCs has been shown to be required to induce Regulatory Tcells (tregs). Addition of ZM4.1, like ZM3.8, blocks the suppressive function of the Tregs in in vitro culture systems with allogenic DC's.Applications Reported: This ZM4.1 antibody has been reported for use in flow cytometric analysis and has been shown to block Treg function in vitro.Applications Tested: This ZM4.1 antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Storage and handling: Use in a sterile environment.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].仅用于科研。不用于诊断过程。
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参考文献： |
| 流式1.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical ImmunologyDendritic cell phenotype in severe asthma reflects clinical responsiveness to glucocorticoids."16-5139 was used in Flow cytometry/Cell sorting to determine whether clinical glucocorticoid sensitivity of severe asthmatics is reflected in differences in peripheral blood dendritic cell subsets."AuthorsChambers ES,Nanzer AM,Pfeffer PE,Richards DF,Martineau AR,Griffiths CJ,Corrigan CJ,Hawrylowicz CM |
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