IL-12/IL-23 p40 Monoclonal Antibody (C8.6), Functional Grade, eBioscience™/IL-12/IL-23 p40 单克隆 (C8.6), 功能抗体, eBioscience™

货号：16-7129-81,16-7129-85,16-7129-025,16-7129-050

规格：50 µg,500 µg,25 mg,50 mg

价格：1044,3274,72266,120443

产品类型：流式抗体

品牌：eBioscience

抗原：IL-12/IL-23 p40

物种：人

宿主：小鼠

抗体亚型：IgG1, kappa

克隆号：C8.6

荧光染料：其它

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类型:	一抗(功能抗体）	同型对照：	Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Functional Grade, eBioscience™
浓度：	1 mg/mL	用法：	Assay-Dependent（ELISA）;Assay-Dependent（中和）；Assay-Dependent（FN）

产品详细信息Description: The C8.6 antibody reacts with the p40 subunit of human IL-12 p70 and human IL-23. IL-12 is a 70 kDa heterodimeric cytokine composed of two covalently linked chains, p40 and p35, and secreted primarily by activated monocytes, macrophages, and dendritic cells. IL-23 is a biologically-related, heterodimeric cytokine composed of disulfide-linked p40 and p19 subunits.Applications Reported: The C8.6 antibody has been reported for use ELISA, ELISPOTand neutralization.Applications Tested: The Functional Grade Purified C8.6 antibody has been tested by LAL assay to verify low endotoxin levels and has been tested for ELISA detection and in bioassay for neutralization of IL-12 p70 and IL-23 bioactivity.The C8.6 antibody at 60.0 ng/mL has been found to inhibit by 50% the biological effects of 1 ng/mL human IL-12 p70 (14-8129) or human IL-23 (14-8239), in corresponding bioassay. Detailed information and protocols about cytokine bioassays and in vitro cytokine neutralization using antibodies can be found in the BestProtocols® section.Storage and handling: Use in a sterile environment.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息IL-12 is an interleukin produced by dendritic cells, neutrophils, macrophages and human lymphoblastoid cells as a result of antigenic stimulation. IL-12 is a heterodimeric cytokine encoded by IL-12A (p35) and IL-12B (p40). IL-23 is a heterodimeric cytokine that shares a subunit with IL-12 (IL-12B) along with an IL-23A (IL-23p19) subunit. Functionally, IL-12 increases the expression of vascular endothelial adhesion molecule-1 on the endothelium, directs leukocytes towards tumors and facilitates the ischemic-hemorrhagic necrosis of the tumor tissue. In comparison, IL-23 plays an important role in stimulating memory T-cells, and is required for the induction, expansion, maintenance and downstream effector functions of Th17 cells, which play a vital role in upregulating neutrophil chemokines and various pro-inflammatory cytokines.仅用于科研。不用于诊断过程。

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参考文献：

ELISA1.PloS oneSalmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells."16-7129 was used in an ELISA assay to show that various TLR agonists and infection with Salmonella can induce interleukin (IL)-23, IL-18 and IL-1β, but not IL-12, production in monocytes and type 1 pro-inflammatory macrophages."Authorsvan de Wetering D,de Paus RA,van Dissel JT,van de Vosse E中和2.International immunologyDistinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists."16-7129 was used in Neutralization experiments to show that IRMs can modulate NK-cell function both in vitro and in vivo and that distinct indirect pathways control human NK-cell activation by TLR-7 and TLR-8 agonists."AuthorsGorski KS,Waller EL,Bjornton-Severson J,Hanten JA,Riter CL,Kieper WC,Gorden KB,Miller JS,Vasilakos JP,Tomai MA,Alkan SS功能检测3.Immunity, inflammation and diseaseInterleukin-25 initiates Th2 differentiation of human CD4(+) T cells and influences expression of its own receptor."16-7129 was used in Functional assays to characterise IL-25 receptor expression on CD4(+) T cells, and determine whether IL-25 plays a role in Th2 differentiation."AuthorsBredo G,Storie J,Shrestha Palikhe N,Davidson C,Adams A,Vliagoftis H,Cameron L

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