CD5 Monoclonal Antibody (UCHT2), PE-Cyanine7
货号：25-0059-42
规格：100 T
价格：3163
产品类型：流式抗体
品牌：eBioscience
抗原：CD5
物种：人
宿主：小鼠
抗体亚型：IgG1, kappa
克隆号：UCHT2
荧光染料：PE-Cy7
| 类型: | 单抗 | 同型对照： | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE-Cyanine7 |
| 浓度： | 5 µL/Test | 用法： | 5 µL (0.5 µg)/test(Flow) |
产品详细信息Description: The UCHT2 monoclonal antibody reacts with human CD5, a 67 kDa protein expressed by a majority of thymocytes and mature T cells and a subset of B cells. Signaling through the CD5 molecule activates T cells and binding of CD5 to its ligand on B cells, CD72, and plays an important role in T-B interaction and proliferation.\\\\The monoclonal antibody UCHT2 recognizes primate CD5.Applications Reported: This UCHT2 antibody has been reported for use in flow cytometric analysis.靶标信息CD5 is a 67 kDa human T-lymphocyte single-chain transmembrane glycoprotein. CD5 is present on all mature T-lymphocytes, on most of thymocytes and on many T-cell leukemias and lymphomas. CD5 also reacts with a subpopulation of activated B-cells and may act as a receptor in regulating T-cell proliferation. CD5 is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas, and activated T cells. Diseases associated with CD5 dysfunction include thymus cancer and Richter's Syndrome.
| 数据 |
| CD5 Antibody (25-0059-42) in FlowStaining of normal human peripheral blood cells with Anti-Human CD19 APC (Product # 17-0199-42) and Mouse IgG1 kappa Isotype Control PE-Cyanine7 (Product # 25-4714-80) (left) or Anti-Human CD5 PE-Cyanine7 (right). Cells in the lymphocyte gate were used for analysis. CD5 Antibody (25-0059-42)Stem cell reports 2017 -Figure 7 HEBCan Rescues Hematopoiesis and T Cell Development in HEB -/- hESCs in OP9-DL4 Co-cultures (A) qRT-PCR analysis for the expression of hematopoietic genes in CD34 + cells sorted from WT, KO + GFP, and KO + HEBCan day-8 (d8) EBs. mRNA levels are shown relative to GAPDH. (B and C) Percentages (B) and numbers (C) of CD45 + cells in d12 and d18 OP9-DL4 co-cultures. (D and E) Flow-cytometric analysis of T cell development from WT, KO + GFP, and KO + HEBCan d8 EB-derived CD34 + cells at d12 (D) and d18 (E) of OP9-DL4 co-culture. Cells are gated on the CD45 + DAPI - population. Error bars represent mean +- SD (n = 3 independent experiments). * p < 0.05, ** p < 0.01, *** p < 0.005 by Student's t test. Plots in (B), (D), and (E) are representative of three independent experiments. |
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