CD4 Monoclonal Antibody (OKT4 (OKT-4)), PE
货号：12-0048-42
规格：100 Tests
价格：2323
产品类型：流式抗体
品牌：Thermo Fisher
物种：人
宿主：小鼠
抗体亚型：IgG2b, kappa
荧光染料：PE
| 抗体类型 | 单抗 | 同型对照： | Mouse IgG2b kappa Isotype Control (eBMG2b), PE |
| 浓度： | 5 µL/Test | 用法： | 5 μL (0.06 μg)/test (Flow) |
| 产品详细信息Description: The OKT4 monoclonal antibody reacts with human CD4, a 59 kDa cell surface glycoprotein expressed by the majority of thymocytes, a subpopulation of mature T cells (T-helper cells) and in low levels on monocytes. CD4 is a receptor for the human immunodeficiency virus (HIV). The OKT4 antibody recognizes a different epitope than the RPA-T4 monoclonal antibody, and these antibodies do not cross-block binding to each other's respective epitopes.Applications Reported: This OKT4 (OKT-4) antibody has been reported for use in flow cytometric analysis.Applications Tested: This OKT4 (OKT-4) antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.06 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017]. |
| 数据 |
| CD4 Antibody (12-0048-42) in FlowStaining of normal human peripheral blood cells with Anti-Human CD8a FITC (Product # 11-0088-42) and Mouse IgG2b K Isotype Control PE (Product # 12-4732-81) (left) or Anti-Human CD4 PE (right). Cells in the lymphocyte gate were used for analysis. |
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| 参考文献： |
| 1.Investigative ophthalmology and visual scienceIntercellular adhesion molecule 1 mediates migration of Th1 and Th17 cells across human retinal vascular endothelium."12-0048 was used in Flow cytometry/Cell sorting to investigate the ability of human Th1- and Th17-polarised cells to cross a simulated human retinal endothelium, and examined the role of IgG superfamily members in this process."AuthorsBharadwaj AS,Schewitz-Bowers LP,Wei L,Lee RW,Smith JR2.European journal of immunologyTh17-related cytokines contribute to recall-like expansion/effector function of HMBPP-specific Vγ2Vδ2 T cells after Mycobacterium tuberculosis infection or vaccination."12-0048 was used in Flow cytometry/Cell sorting to examine the involvement of cytokines in the adaptive immune response to bacterial infection."AuthorsShen H,Wang Y,Chen CY,Frencher J,Huang D,Yang E,Ryan-Payseur B,Chen ZW3.Nature communicationsComplement receptor CD46 co-stimulates optimal human CD8+T cell effector function via fatty acid metabolism."Published figure using CD4 monoclonal antibody (Product # 12-0048-42) in Flow Cytometry"4.AtherosclerosisExvivo culture of human atherosclerotic plaques: A model to study immune cells in atherogenesis."Published figure using CD4 monoclonal antibody (Product # 12-0048-42) in Flow Cytometry"5.Stem cell reportsTargeted Disruption of TCF12 Reveals HEB as Essential in Human Mesodermal Specification and Hematopoiesis."Published figure using CD4 monoclonal antibody (Product # 12-0048-42) in Flow Cytometry" |
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