CD28 Monoclonal Antibody (CD28.2), PE
货号：12-0289-41,12-0289-42
规格：25 T,100 T
价格：1011,2230
产品类型：流式抗体
品牌：eBioscience
抗原：CD28
物种：人
宿主：小鼠
抗体亚型：IgG1, kappa
克隆号：CD28.2
荧光染料：PE
| 类型: | 单抗 | 同型对照： | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE |
| 浓度： | 5 µL/Test | 用法： | 5 µL (0.25 µg)/test(Flow) |
产品详细信息Description: The CD28.2 monoclonal antibody reacts with the human CD28 molecule, a 44 kDa homodimer expressed by thymocytes, mature T cells and plasma cells. CD28 is a ligand for CD80 (B7-1) and CD86 (B7-2) and is a potent co-stimulator of T cells. Signaling through CD28 augments IL-2 and IL-2 receptor expression as well as cytotoxicity of CD3-activated T cells.Applications Reported: The CD28.2 antibody has been reported for use in flow cytometric analysis.Applications Tested: The CD28.2 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.25 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. CD28 is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes. Moreover, CD28 is the critical T cell costimulatory receptor that provides the cell the important second activation signal by binding CD80 and CD86 which are expressed by antigen presenting cells. In addition to its co-stimulation role, CD28 functions by preventing Tcells from entering an anergic-hyporesponsive state or from undergoing premature apoptotic cell death. In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28. In the thymus, CD28 expression is highest on immature CD3-, CD8+ and CD4+8+ cells, and on CD4-8- cells that express alpha/beta and gamma/delta TCR. The level of CD28 on mature CD4+ and CD8+ alpha/beta TCR+ thymocytes is two- to fourfold lower than on the immature cells. Diseases associated with CD28 dysfunction include mycosis fungiodes and Sezary's Disease.
| 数据 |
| CD28 Antibody (12-0289-41) in FlowStaining of normal human peripheral blood cells with Anti-Human CD19 APC (Product # 17-0199-42) and Mouse IgG1 K Isotype Control PE (Product # 12-4714-81) (left) or Anti-Human CD28 PE (right). Cells in the lymphocyte gate were used for analysis. CD28 Antibody (12-0289-41)Molecular medicine reports 2016 -Published figure using CD28 monoclonal antibody (Product # 12-0289-41) |
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| 参考文献 |
| 1. Journal of virologyIntensity of the humoral response to cytomegalovirus is associated with the phenotypic and functional status of the immune system.2. Nature communicationsCo-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors.3. Scientific reportsCRISPR-Cas9 mediated efficient PD-1 disruption on human primary T cells from cancer patients.4. Molecular medicine reportsCD28 family of receptors on Tcells in chronic HBV infection: Expression characteristics, clinical significance and correlations with PD-1 blockade.5. Scientific reportsCRISPR-Cas9 mediated efficient PD-1 disruption on human primary T cells from cancer patients. |
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