CD278 (ICOS) Monoclonal Antibody (7E.17G9), Biotin
货号：13-9942-85
规格：500μg
价格：2987
产品类型：流式抗体
品牌：Thermo Fisher
物种：小鼠
宿主：大鼠
抗体亚型：IgG2b, kappa
荧光染料：Biotin
| 抗体类型 | 一抗 | 同型对照： | Rat IgG2b kappa Isotype Control (eB149/10H5), Biotin |
| 浓度： | 0.5 mg/mL | 用法： | 0.06 μg/test (Flow)； |
| 产品详细信息Description: The 7E.17G9 monoclonal antibody reacts with mouse ICOS (Inducible COStimulatory molecule), a T cell specific molecule and a third member of the CD28/CTLA-4 family. A homodimer of 47-57 kDa, ICOS is expressed on activated T cells, has potent costimulatory activity for T cell activation and proliferation and is required for humoral immune response. ICOS binds to its ligand on activated APC including B cells called B7h/B7RP-1 and is thought to play a protective role in inflammatory autoimmune diseases. ICOS may be involved in the development of Th2 cells.Applications Reported: 7E.17G9 has been reported for use in flow cytometric analysis.Applications Tested: The 7E.17G9 antibody has been tested by flow cytometric analysis of unstimulated and Con A-stimulated (3 day) mouse splenocytes and can be used at less than or equal to 0.06 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Filtration: 0.2 µm post-manufacturing filtered.靶标信息CD278 belongs to the CD28 and CTLA-4 cell-surface receptor family and is highly expressed in activated T-cells. It is essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. It enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. |
| 数据 |
| CD278 (ICOS) Antibody (13-9942-85) in FlowStaining of unstimulated (left) and 3-day ConA activated (right) BALB/c splenocytes with 0.03 µg of Rat IgG2b Isotype Control Biotin (Product # 13-4031-82) (open histogram) or 0.03 µg of Anti-Mouse CD278 (ICOS) Biotin followed by Streptavidin PE (Product # 12-4317-87). Viable cells were analyzed. |
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| 参考文献： |
| 1.European journal of immunologyNCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation."13-9942 was used in Flow cytometry/Cell sorting to provide evidence for the role of NCR1 in antibody response to mouse cytomegalovirus infection."2.Nature communicationsExtrafollicular CD4+T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease."Published figure using CD278 (ICOS) monoclonal antibody (Product # 13-9942-81) in Flow Cytometry"3.Nature communicationsRoquin targets mRNAs in a 3'-UTR-specific manner by different modes of regulation."Published figure using CD278 (ICOS) monoclonal antibody (Product # 13-9942-81) in Flow Cytometry"4.European journal of immunologyNCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation."13-9942 was used in Flow cytometry/Cell sorting to provide evidence for the role of NCR1 in antibody response to mouse cytomegalovirus infection."5.Nature communicationsRoquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40."13-9942 was used in Flow cytometry/Cell sorting to reveal an unexpected recognition of hexaloop cis elements for the posttranscriptional regulation of target messenger RNAs by Roquin." |
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