Mouse anti Human TAB1 antibody
货号:VMA00576
规格:100μl
价格:2916
产品类型:免疫组化一抗
品牌:Bio-Rad
抗原:TAB1
物种:人
宿主:小鼠
抗体亚型:IgG2a
荧光染料:Purified
产品介绍 | | |
Mouse anti Human TAB1 antibodyrecognizes the TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, also known as TAK1-binding protein 1, mitogen-activated protein kinase kinase kinase 7-interacting protein 1 or transforming growth factor beta-activated kinase-binding protein 1.The protein encoded by TAB1 gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha). Alternatively spliced transcript variants encoding distinct isoforms have been reported (provided by RefSeq, Jul 2008).Mouse anti Human TAB1 antibody detects a band of 60 kDa. The antibody has been extensively validated for western blotting using whole cell lysates. |
产品详情 | | |
Target Species | Human |
Product Form | Purified IgG - liquid |
Preparation | Mouse monoclonal antibody purified by affinity chromatography on Protein G from ascites. |
Buffer Solution | Phosphate buffered saline |
Preservative Stabilisers | 0.09% Sodium Azide (NaN3)1% Bovine Serum Albumin<50% Glycerol |
Immunogen | E. coli-derived recombinant human TAB1 (amino acids 1 - 300) |
Acknowledgements | PrecisionAb is a trademark of Bio-Rad Laboratories. |
Regulatory | For research purposes only |
Guarantee | 12 months from date of despatch. |
存储条件 | | |
Store undiluted at -20°C, avoiding repeated freeze thaw cycles. |
应用 | | |
Application Name | Verified | Min Dilution | Max Dilution |
Western Blotting | √ | 1/1000 | |
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.Flow CytometryUse 10ul of the suggested working dilution to label 106cells or 100ul human whole blood. |
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技术参数 产品应用 wb
产品类型 多克隆抗体
推荐用于 wb
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