mouse anti human COMPLEMENT FACTOR H
货号：MCA2614
规格：0.1 mg
价格：5925
产品类型：流式抗体
品牌：Bio-Rad
抗原：Complement Factor H
物种：人
宿主：小鼠
抗体亚型：IgG1
克隆号：028B-244.2.10X (10-10)
荧光染料：Purified
| 产品介绍 | | |
| Mouse anti Human Complement Factor H antibody, clone 028B-244.2.10X (10-10)recognizes human complement factor H which exists in 2 forms. The most common form, of 150 kDa, and the less common form of 43 kDa. Factor H is secreted by the liver into the blood serum. It is important in regulating the complement pathway, preventing unnecessary inflammation which can damage the host tissue.Complement factor H functions as a cofactor in the inactivation of C3b by factor I. It makes C3b susceptible to cleavage by factor I, resulting in iC3b. Factor H also inhibits the formation of the C3bBb complex (C3 convertase) and increases the rate of dissociation of both C3 convertase and the (C3b)NBB complex (C5 convertase). This prevents these components of the classical and of alternative complement pathways from forming a positive feedback loop.Mutations in factor H are associated with hemolytic-uremic syndrome, age-related macular degeneration, membranoproliferative glomerulonephritis (MPGN) type II and chronic hypocomplementemic nephropathy. |
| 产品详情 | | |
| Target Species | Human |
| Product Form | Purified Ig - liquid |
| Preparation | Purified IgG prepared by affinity chromatography on Protein A from ascites |
| Buffer Solution | Borate buffered saline |
| Immunogen | Purified human complement factor H from serum. |
| Approx. Protein Concentrations | Current, batch-specific concentration 1.11 mg/ml |
| Preservative Stabilisers | 0.1% Sodium Azide (NaN3) |
| Regulatory | For research purposes only |
| Guarantee | Guaranteed until date of expiry. Please see product label. |
| 存储条件 | | |
| This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light. |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| ELISA | √ | | |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
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| Goat anti Mouse IgG:HRP (Rat Adsorbed) | STAR77 | C;E;P | 0.5mg |
| 文献 |
| 1.Alexander JJ & Quigg RJ (2007) The simple design of complement factor H: Looks can be deceiving.Mol Immunol. 44 (1-3): 123-32.2.Harrison, R.A. & Lachmann, P.J. (1980) The physiological breakdown of the third component of human complement.Mol Immunol. 17 (1): 9-20. |
技术参数 产品应用 Flow;IHC(F);WB;ELISA
产品类型 单克隆抗体
推荐用于 Flow;IHC(F);WB;ELISA
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