mouse anti human CD221:PE
货号：MCA2344PE
规格：100 Tests
价格：3995
产品类型：流式抗体
品牌：Bio-Rad
抗原：CD221
物种：人
宿主：小鼠
抗体亚型：IgG1
克隆号：1H7
荧光染料：PE
| 产品介绍 | | |
| Mouse anti Human CD221 antibody, clone 1H7recognizes human CD221, a ~155 kDa receptor tyrosine kinase, also known as Insulin-like growth factor I receptor (IGF-I Receptor). CD221 is composed of two extracellular alpha-subunits and two transmembrane beta-subunits. Clone 1H7 recognizes an epitope in the alpha subunits of CD221, demonstrated by western blotting (Liet al.1993).CD221 is expressed in a range of tissues, including kidney, liver, placenta, mammary gland, brain, ovary and skin.The ligands for CD221 include IGF-I and IGF-II, which bind to CD221 and activate tyrosine kinase activity, resulting in phosphorylation of several intracellular signaling proteins. Clone 1H7 is reported to partially block binding of IGF-I and IGF-II to CD221 (Liet al.1993). |
| 产品详情 | | |
| Target Species | Human |
| Product Form | Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilized |
| Preparation | Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant |
| Reconstitution | Reconstitute with 1 ml distilled water |
| Buffer Solution | Phosphate buffered saline |
| Immunogen | Purified human placental IGF-I receptor. |
| Preservative Stabilisers | 0.09%Sodium Azide |
| Max Ex/Em | Fluorophore | Excitation Max (nm) | Emission Max (nm) |
| RPE 488nm laser | 496 | 578 |
| Regulatory | For research purposes only |
| Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| Prior to reconstitution store at +4℃.Following reconstitution store at +4℃.DO NOT FREEZE.This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use. |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| Flow Cytometry | √ | | |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
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| 文献 |
| 1.Li, S.L.et al.(1993) Two new monoclonal antibodies against the alpha subunit of the human insulin-like growth factor-I receptor.Biochem Biophys Res Commun. 196 (1): 92-8.2.Beauvais, D.M. & Rapraeger, A.C. (2010) Syndecan-1 couples the insulin-like growth factor-1 receptor to inside-out integrin activation.J Cell Sci. 123 (Pt 21): 3796-807.3.Krieger, C.C.et al.(2016) Thyrotropin/IGF-1 receptor crosstalk in Graves' ophthalmopathy pathogenesis.J Clin Endocrinol Metab. Apr 4: jc20161315. [Epub ahead of print]4.van Valen, F.et al.(2012) A Novel Role of IGF1 in Apo2L/TRAIL-Mediated Apoptosis of Ewing Tumor Cells.Sarcoma. 2012: 782970. |
技术参数 产品应用 Flow
产品类型 单克隆抗体
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