Rabbit anti Human UBC13 antibody
货号：AHP974
规格：100 µl
价格：4650
产品类型：免疫组化一抗
品牌：Bio-Rad
抗原：UBC13
物种：人
宿主：兔
抗体亚型：IgG
荧光染料：Purified
| 产品介绍 | | |
| Rabbit anti Human UBC13 antibodyrecognizes UBC13, also known as ubiquitin-conjugating enzyme E2 N (UBE2N), an important component of the toll-like receptor and interleukin-1R signalling pathway.UBC13 is a DNA-damage inducible protein which forms part of an enzyme complex, with UEV1A, that indirectly activates TAK1 via the ubiquitination of TRAF-6. Ubiquitin modification of proteins is important for error-free DNA repair and for targeting of short-lived or abnormal proteins for degradation (Marteinet al.2009).Rabbit anti Human UBC13 antibody detects ubiquitin-conjugating enzyme E2 N as a band of 17 kDa in a wide range of human cell line lysates. Cross reactivity with rodent cell lines is also observed. |
| 产品详情 | | |
| Target Species | Human |
| Western Blotting | Rabbit anti UBC13 detects a band of approximately 17 kDa in K562 cell lysates. |
| Product Form | Purified IgG - liquid |
| Preparation | Rabbit polyclonal antibody purified by affinity chromatography |
| Buffer Solution | Phosphate buffered saline |
| Preservative Stabilisers | 0.09% Sodium Azide (NaN3) |
| Immunogen | A 15 amino acid peptide located near the human UBC13 C-terminus. |
| Approx. Protein Concentrations | IgG concentration 1.0 mg/ml |
| Regulatory | For research purposes only |
| Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| Store undiluted at -20℃, avoiding repeated freeze thaw cycles. |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| Western Blotting | √ | | 1/1000 |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
| 二抗 |
| Description | Product Code | Applications | Pack Size |
| Goat anti Rabbit IgG (H/L):HRP | STAR208P | E,WB | 1mg |
| 文献 |
| 1.Stagg, H.R.et al.(2009) The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER.J Cell Biol. 186 (5): 685-92.2.Burr, M.L.et al.(2013) MHC class I molecules are preferentially ubiquitinated on endoplasmic reticulum luminal residues during HRD1 ubiquitin E3 ligase-mediated dislocation.Proc Natl Acad Sci U S A. 110 (35): 14290-5. |
技术参数 产品应用 wb
产品类型 多克隆抗体
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