Applications

FA

Synonyms:

ST093553, AC1MFWGY, Hedgehog pathway inhibitor 1

Formulation:

Crystalline solid

Chemical Name:

2-methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate

Molecular Formula:

C₂₇H₂₉NO₆

Molecular Weight:

463.5

CAS Number

599150-20-6

Purity:

≥95%

Storage Conditions:

Product should be kept at -20°C.

References:

Xu, Y., Chenna, V., Hu, C., Sun, H. X., Khan, M., Bai, H., ... & Anders, R. A. (2012). Polymeric nanoparticle-encapsulated hedgehog pathway inhibitor HPI-1 (NanoHHI) inhibits systemic metastases in an orthotopic model of human hepatocellular carcinoma.Clinical Cancer Research,18(5), 1291-1302.

Hyman, J. M., Firestone, A. J., Heine, V. M., Zhao, Y., Ocasio, C. A., Han, K., ... & Chen, J. K. (2009). Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade.Proceedings of the National Academy of Sciences,106(33), 14132-14137.

Merchant, A. A., & Matsui, W. (2010). Targeting Hedgehog—a cancer stem cell pathway.Clinical Cancer Research,16(12), 3130-3140.