Recombinant Human TGF-β3
货号：100-36E-10,100-36E-100,100-36E-1000,100-36E-2,100-36E-250,100-36E-50,100-36E-500
规格：10ug,100ug,1mg,2ug,250ug,50ug,500ug
价格：1560,12176,48759,640,21291,7297,31632
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：The three mammalian isoforms of TGF-β, TGF-β1, β2, and β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility, as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes, including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes, which are stored at the cell surface and in the extracellular matrix. The release of the biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. The physiological role of TGF-β3 is still unknown, but its expression pattern suggests a role in the regulation of certain development processes. Recombinant Human TGF-β3 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.来源:E.coli别名:Transforming Growth Factor-β3氨基酸序列:ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:TheED50was determined by TGF-β3’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107units/mg.Calculated Molecular Weight:25 kDaAccession Number:P10600Gene ID:7043交叉反应:Cow,Dog,Horse,Human,Human + Rat,Human + Virus,Mouse,Pig,Rat,Sheep原产国：USA |
product.subtitle.recentcitations |
第一作者 | Delaine-Smith, R M |
标题 | Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer. |
文献引用 | Iscience; 24(6) pg102674 |
PubMed Id | 34189438 |
第一作者 | Shao, R |
标题 | H3K36 methyltransferase NSD1 regulates chondrocyte differentiation for skeletal development and fracture repair. |
文献引用 | Bone Research; 9(1) pg30 |
PubMed Id | 34099628 |
第一作者 | Stykel, M G |
标题 | α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology. |
文献引用 | Cell Reports; 35(6) pg109099 |
PubMed Id | 33979611 |
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