货号：310-06-5

规格：5ug

价格：825

产品类型：细胞因子添加物

品牌：PeproTech

310-06-5

TNF-related weak inducer of apoptosis, TNFSF12, DR3LG, Apo3 Ligand

TWEAK belongs to the TNF family of ligands, and signals through TWEAKR, also known as TNFRSF12A. TWEAK is expressed in a variety of tissues, including the adult heart, pancreas, skeletal muscle, small intestine, spleen and peripheral blood lymphocytes. TWEAK has the ability to induce NF-κB activation and chemokine secretion, and to exert an apoptotic activity in certain cells, such as HT-29 human adenocarcinoma cells when cultured in the presence of IFN-γ. TWEAK also promotes proliferation and migration of endothelial cells. The human TWEAK gene encodes for a 249 amino acid type II transmembrane protein, which contains a 21 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 207 amino acid extracellular domain. Recombinant Human TWEAK is a soluble 17.0 kDa polypeptide (154 amino acid residues) comprising the TNF-homologous region of TWEAK, and is generated by proteolytic processing of the full length membrane-anchored TWEAK protein.

MKGRKTRARR AIAAHYEVHP RPGQDGAQAG VDGTVSGWEE ARINSSSPLR YNRQIGEFIV TRAGLYYLYC QVHFDEGKAV YLKLDLLVDG VLALRCLEEF SATAASSLGP QLRLCQVSGL LALRPGSSLR IRTLPWAHLK AAPFLTYFGL FQVH

E.coli

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Assay #1:TheED₅₀as determined by the dose-dependent stimulation of IL-8 production by Human PBMC is less than 10 ng/ml.Assay #2:TWEAK weakly induces the death of HT29 cells when cultured in the presence of IFN-γ. TheED₅₀for this effect is between 30-45 ng/ml.

Mouse, Human

除了5μg，还提供：25μg；100μg；250μg；500μg；1mg，详情咨询：010-57438396