Trop2 (EGP-1) Monoclonal Antibody (MR54), PE, eBioscience™
货号：12-6024-42
规格：100 tests
价格：2944
产品类型：流式抗体
品牌：eBioscience
物种：人
宿主：小鼠
抗体亚型：IgG
荧光染料：PE
| Tested Species reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Recommended Isotype Control | Mouse IgG2a kappa Isotype Control, PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MR54 |
| Conjugate | PE See Additional Formats |
| Excitation/Emission Profile | View spectra |
| Form | Liquid |
| Concentration | 5 µl/Test |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 0.1% gelatin, 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage conditions | 4° C, store in dark, DO NOT FREEZE! |
| RRID | AB_2572648 |
Product Specific Information
Description: This MR54 monoclonal antibody reacts with human Trop-2, which is also known as Tumor-Associated Calcium Signal Transducer 2 (TACSTD2) and EGP-1. This type I transmembrane glycoprotein is expressed on trophoblast (syncytiotrophoblast and cytotrophoblast), epithelial, and most human carcinoma cells. Trop-2 plays a role in calcium-mediated signaling. Trop-2 has also been reported as an oncogene, with expression being correlated with tumorigenesis, metastasis, and anchorage-independent growth.Applications Reported: This MR54 antibody has been reported for use in flow cytometric analysis.Applications Tested: This MR54 antibody has been pre-titrated and tested by flow cytometric analysis of MCF7 cell line. This can be used at 5 µL (0.125 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.Filtration: 0.2 µm post-manufacturing filtered.
Background/Target Information
TROP2 is a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor. Mutations of its gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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