CD309 (FLK1) Monoclonal Antibody (Avas12a1), APC

货号：17-5821-80,17-5821-81

规格：25μg,50μg

价格：1545,2892

产品类型：流式抗体

品牌：Thermo Fisher

物种：小鼠

宿主：大鼠

抗体亚型：IgG

克隆号：Avas12a1

荧光染料：APC

抗体类型:	单抗	同型对照：	Rat IgG2a kappa Isotype Control, APC, eBioscience™
免疫原性：		用法：	0.5 µg/test(Flow）

Description: The Avas12a1 monoclonal antibody reacts with mouse Flk-1, also known as vascular endothelial growth factor receptor 2 (VEGFR2). Flk-1 is a receptor tyrosine kinase involved in vascular endothelial tissue development and is expressed on endothelial cells during embryonic stages and some endothelial tissues in the adult.Applications Reported: This Avas12a1 antibody has been reported for use in flow cytometric analysis.Applications Tested: This Avas12a1 antibody has been tested by flow cytometric analysis of bEnd.3 cells. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.Filtration: 0.2 µm post-manufacturing filtered.Background/Target InformationVascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

数据

CD309 (FLK1) Antibody (17-5821-81) in Flow Staining of the bEnd-3 cell line with 0.25 µg of Rat IgG2a K Isotype Control APC (Product # 17-4321-81) (open histogram) or 0.25 µg of Anti-Mouse CD309 (FLK1) APC (filled histogram). Total viable cells were used for analysis.

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参考文献：

1. JCI insightAntifibrotic role of vascular endothelial growth factor in pulmonary fibrosis.By clicking the link above, you will be redirected to the Benchsci website.Disclaimer2. Scientific reportsActivation of the TGFβ pathway impairs endothelial to haematopoietic transition."17-5821 was used in Flow cytometry/Cell sorting to assess the contribution of transforming growth factor-beta 1 signalling in key haematological developmental processes during embryogenesis."AuthorsVargel Ö,Zhang Y,Kosim K,Ganter K,Foehr S,Mardenborough Y,Shvartsman M,Enright AJ,Krijgsveld J,Lancrin C3. Cell reportsErk5 Is a Key Regulator of Naive-Primed Transition and Embryonic Stem Cell Identity."17-5821 was used in Flow cytometry/Cell sorting to investigate the mechanisms that control naive-primed pluripotent transition of embryonic stem cells."AuthorsWilliams CA,Fernandez-Alonso R,Wang J,Toth R,Gray NS,Findlay GM4. Immune networkInduction of Indoleamine 2,3-dioxygenase by Pre-treatment with Poly(I:C) May Enhance the Efficacy of MSC Treatment in DSS-induced Colitis."17-5821 was used in Flow cytometry/Cell sorting to determine whether TLR ligands can enhance the therapeutic efficacy of mesenchymal stem cells for treating inflammatory disorders."AuthorsRyu DB,Lim JY,Lee SE,Park G,Min CK5. Stem cell reportsHistone Demethylases KDM4A and KDM4C Regulate Differentiation of Embryonic Stem Cells to Endothelial Cells."17-5821 was used in Flow cytometry/Cell sorting to demonstrate the essential role of KDM4A and KDM4C in murine embryonic stem cell differentiation to endothelial cells."AuthorsWu L,Wary KK,Revskoy S,Gao X,Tsang K,Komarova YA,Rehman J,Malik AB

技术参数

产品应用 Flow

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