Bovine IL-21 ELISA Kit/牛IL-21 ELISA试剂盒
货号：EB11RB,EB11RBX5,EB11RBX10
规格：96 Tests,5X96 Tests,10X96 tests
价格：6641,29884,57271
产品类型：Platinum ELISA
品牌：Thermo Fisher
物种：其它
宿主：其它
抗体亚型：其它
荧光染料：其它
灵敏度 | 0.41 ng/mL |
| 检测范围 | 0.41-100 ng/mL |
样本类型/体积 | 血清 50 μL 血浆 50 μL 上清液 50 μL |
操作时间 | 1 hr 20 min |
测试时间 | 4 hr 45 min |
Homogenous (no wash) | No |
| 批间变异系数（CV） | <12% |
| 批内变异系数（CV） | <10% |
仪器设备 | Colorimetric Microplate Reader 酶标仪 |
规格 | 5 x 96 Tests |
组份 | - 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖 |
储存温度 | 2-8℃ |
| Protein name | IL-21 |
| Protein aliases | IL-21, Interleukin-21 |
物种（Tested） | 牛 |
试剂盒类型 | Sandwich ELISA Kit |
标记（染料） | HRP |
| 检测抗体偶联物 | Biotin |
| Gene aliases | IL21 |
| Gene ID | (Bovine) 378475 |
| Gene symbol | IL21 |
| Bovine IL-21 quantitates bovine IL-21 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant bovine IL-21.牛IL-21定量测定血清，血浆，上清液中的牛IL-21。该检测试剂盒将只识别天然和重组牛IL-21。Target information 靶标信息IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by Natural Killer Cells (NKT), T helper (Th) 17 and T follicular helper (TFH) cells. In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which leads to additional transcriptional activation by Bcl6. As with IFN gamma for Th1 and IL-4 for Th2 cells, IL-21 is critical for TFH cell development and effector function. IL-21 plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells, stimulation of IgG production and induction of apoptotic signaling in naive B cells. In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and ROR gamma t lead to upregulation of the IL-23R, thereby preparing Th17 cells for maturation and maintenance by the inflammatory cytokine IL-23. While upregulating IRF4 and ROR gamma t, IL-21 also mediates the downregulation of Foxp3. IL-21 deficient mice are protected from developing colitis upon chemical treatment by their inability to upregulate Th17-associated molecules. In comparison, elevated levels of IL-21 are present in chemically-induced colitis mouse models.IL-21是一种17 kDa的免疫调节细胞因子，主要由自然杀伤细胞（NKT），T辅助（Th）17和T滤泡辅助（TFH）细胞产生。在TFH细胞中，IL-21表达导致通过IL-21受体（IL-21R）和STAT3的自分泌信号传导，从而导致Bcl6进行额外的转录激活。与Th1细胞的IFNγ和Th2细胞的IL-4一样，IL-21对于TFH细胞发育和效应子功能至关重要。 IL-21在依赖T细胞的B细胞分化为浆细胞和记忆细胞，刺激IgG产生以及诱导天然B细胞中凋亡信号转导中发挥作用。在Th17细胞中，IL-21的表达和通过STAT3，IRF4和RORγt引起的自分泌反馈导致IL-23R上调，从而为Th17细胞做好准备，使其通过炎性细胞因子IL-23进行成熟和维持。 IL-21在上调IRF4和RORγt的同时，还介导Foxp3的下调。 IL-21缺陷小鼠由于无法上调与Th17相关的分子而受到化学治疗，从而免受结肠炎的侵袭。相比之下，化学诱导的结肠炎小鼠模型中存在IL-21的升高水平。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。 |
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