CD244 Monoclonal Antibody (eBioPP35 (PP35)), Functional Grade, eBioscience™/CD244 单克隆 (eBioPP35 (PP35)),功能抗体, eBioscience™

货号：16-2449-81,16-2449-025,16-2449-050

规格：50 µg,25 mg,50mg

价格：934,72266,120443

产品类型：流式抗体

品牌：eBioscience

抗原：CD244

物种：人

宿主：小鼠

抗体亚型：其它

克隆号：eBioPP35 (PP35)

荧光染料：其它

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类型:	一抗(功能抗体）	同型对照：	Rat IgG1 kappa Isotype Control (eBRG1), Functional Grade, eBioscience™
浓度：	1 mg/mL	用法：	0.5 µg/test（Flow）

产品详细信息Description: The eBioPP35 monoclonal antibody reacts with human CD244, also known as 2B4, p38, NK-cell activation-inducing ligand, signaling lymphocyte activation molecule family member 4, and natural killer cell receptor 2B4. Human CD244 is a 38 kD protein expressed on NK cells, a subset of CD8+ T cells, gammadelta T cells, monocytes, basophils, mast cells, and eosinophils. Binding of CD244 to its ligand, CD48, results in NK cell activation. Costaining experiments with eBioC1.7 suggest that both antibodies recognize different epitopes.Applications Tested: This eBioPP35 (PP35) antibody has been tested by flow cytometric analysis of human peripheral blood cells.Storage and handling: Use in a sterile environment.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息CD244 (2B4, SLAMF4) is a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via CD244 is thought to modulate NK-cell cytolytic activity. CD244 interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells. Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in the pathology of this autoimmune disease. Diseases associated with CD244 dysfunction include rheumatoid arthritis and lymphoproliferative syndrome. Alternatively spliced transcript variants encoding different isoforms of CD244 have been found for this gene.仅用于科研。不用于诊断过程。

数据

CD244 Antibody (16-2449-81) in FlowStaining of normal human peripheral blood cells with Anti-Human CD8a APC (Product # 17-0088-42) and 0.25 µg of Mouse IgG1 K Isotype Control Functional Grade Purified (Product # 16-4714-82) (left) or 0.25 µg of Anti-Human CD244 Functional Grade Purified (right). Cells in the lymphocyte gate were used for analysis.

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参考文献：

功能检测1.Frontiers in immunologyTargeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells."16-2449 was used in Functional assays to compare the efficacy of dendritic cell receptor-ligand blockades at various immune checkpoints on T cell activation, an suggest targets for enhanced immunotherapy."AuthorsLichtenegger FS,Rothe M,Schnorfeil FM,Deiser K,Krupka C,Augsberger C,Schlüter M,Neitz J,Subklewe M2.The Journal of allergy and clinical immunologyGenetic predisposition to hemophagocytic lymphohistiocytosis: Report on 500 patients from the Italian registry."16-2449 was used in Functional assays to report and analyse the data collected on 500 patients who received a confirmed clinical diagnosis of Hemophagocytic lymphohistiocytosis over 25 years from the italian registry."AuthorsCetica V,Sieni E,Pende D,Danesino C,De Fusco C,Locatelli F,Micalizzi C,Putti MC,Biondi A,Fagioli F,Moretta L,Griffiths GM,Luzzatto L,Aricò M3.The Journal of allergy and clinical immunologyDiagnosing XLP1 in patients with hemophagocytic lymphohistiocytosis."16-2449 was used in Functional assays to characterise a cohort of patients with HLH and XLP1 for SAP expression and 2B4 function in lymphocytes."AuthorsMeazza R,Tuberosa C,Cetica V,Falco M,Parolini S,Grieve S,Griffiths GM,Sieni E,Marcenaro S,Micalizzi C,Montin D,Fagioli F,Moretta A,Mingari MC,Moretta L,Notarangelo LD,Bottino C,Aricò M,Pende D中和4.PloS oneInvolvement of CD244 in regulating CD4+ T cell immunity in patients with active tuberculosis."16-2449 was used in Blocking experiments to investigate the expression and function of CD244/2B4 on CD4(+) T cells from active TB patients and latent infection individuals."AuthorsYang B,Wang X,Jiang J,Cheng X5.PLoS pathogensDual function of the NK cell receptor 2B4 (CD244) in the regulation of HCV-specific CD8+ T cells."16-2449 was used in Blocking experiments to analyse the role of 2B4 as an additional costimulatory receptor regulating CD8+ T cell function."AuthorsSchlaphoff V,Lunemann S,Suneetha PV,Jaroszewicz J,Grabowski J,Dietz J,Helfritz F,Bektas H,Sarrazin C,Manns MP,Cornberg M,Wedemeyer H

技术参数

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