产品介绍 |
| Rabbit anti c-Jun antibodyrecognizes c-Jun, also known as p39. The c-Jun transcription factor is encoded by the c-Jun oncogene and dimerizes with c-Fos, JDP and ATF family members to form the AP-1 transcription factor (Eferl and Wagner 2003). AP-1 is activated by a variety of stimuli including cytokines, stress and growth factors, and plays a critical role in cellular processes ranging from proliferation to apoptosis. c-Jun becomes phosphorylated on Serine 63 and Serine 73 by MAPK8 (SAPK/JNK) and PLK3, which regulate c-Jun transcription. c-Jun has been implicated in early tumor development, invasion and metastasis, and due to these findings has been identified as a target for cancer therapies. |
产品详情 |
Target Species | Mouse |
Species Cross-Reactivity | Target SpeciesCross Reactivity |
| Human √ |
| Rat √ |
| N.B. Antibody reactivity and working conditions may vary between species. |
Product Form | Purified IgG - liquid |
Preparation | Purified IgG prepared by affinity chromatography |
AntiserumPreparation | Antiserum to c-Jun was raised by repeated immunisation of rabbits with highly purified antigen |
Buffer Solution | Phosphate buffered saline |
Preservative Stabilisers | 0.1% Sodium Azide (NaN3)0.2% Gelatin |
Immunogen | Peptide mapping to the amino terminus of mouse c-Jun |
Approx. Protein Concentrations | IgG concentration 0.2 mg/ml |
Regulatory | For research purposes only |
Guarantee | 12 months from date of despatch |
存储条件 |
Store at +4℃. DO NOT FREEZE.This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use. |
应用 |
Application Name | Verified | Min Dilution | Max Dilution |
Western Blotting | √ | 1/400 | |
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.- Western Blotting
- Rabbit anti mouse c-Jun recognizes a band of approximately 36 kDa when run under reducing conditions
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