Garcinol

2024-10-15

Garcinol

货号:7883034-25,7883034-10

规格:25mg,10mg

价格:2310,990

产品类型:小分子化合物

品牌:Biogems

Garcinol is a polyisoprenylated benzophenone derivative and histone acetyltransferase (HAT) PCAF and p300 inhibitor. It has been used to inhibit the growth of cancel cell lines and promote ex vivo expansion of human stem cells. Garcinol also exhibits antioxidative and chelating activity and predominantly down regulates the global gene expression in HeLa cells.

Additional Information

Applications

FA

Synonyms:

Camboginol, CCRIS 9029, CHEMBL502489

Formulation:

Crystalline solid

Chemical Name:

(1S,3E,5R,7R)-3-[(3,4-dihydroxyphenyl)-hydroxymethylidene]-6,6-dimethyl-5,7-bis(3-methylbut-2-enyl)-1-[(2S)-5-methyl-2-prop-1-en-2-ylhex-4-enyl]bicyclo[3.3.1]nonane-2,4,9-trione

Molecular Formula:

C38H50O6

Molecular Weight:

602.8

CAS Number

78824-30-3

Purity:

≥95%

Storage Conditions:

Product should be kept at -20°C.

References:

Yamaguchi, F., Ariga, T., Yoshimura, Y., & Nakazawa, H. (2000). Antioxidative and anti-glycation activity of garcinol from Garcinia indica fruit rind.Journal of Agricultural and Food Chemistry,48(2), 180-185.

Balasubramanyam, K., Altaf, M., Varier, R. A., Swaminathan, V., Ravindran, A., Sadhale, P. P., & Kundu, T. K. (2004). Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression.Journal of Biological Chemistry,279(32), 33716-33726.

Pan, M. H., Chang, W. L., Lin-Shiau, S. Y., Ho, C. T., & Lin, J. K. (2001). Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells.Journal of agricultural and food chemistry,49(3), 1464-1474.

技术参数
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